Τίτλος:
Stereotactic Arrhythmia Radioablation as a Novel Treatment Approach for
Cardiac Arrhythmias: Facts and Limitations
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Stereotactic ablative radiotherapy (SABR) is highly focused radiation
therapy that targets well-demarcated, limited-volume malignant or benign
tumors with high accuracy and precision using image guidance.
Stereotactic arrhythmia radioablation (STAR) applies SABR to treat
cardiac arrhythmias, including ventricular tachycardia (VT) and atrial
fibrillation (AF), and has recently been a focus in research. Clinical
studies have demonstrated electrophysiologic conduction blockade and
histologic fibrosis after STAR, which provides a proof of principle for
its potential for treating arrhythmias. This review will present the
basic STAR principles, available clinical study outcomes, and how the
technique has evolved since the first pre-clinical study. In addition to
the clinical workflow, focus will be given on the process for
stereotactic radiotherapy Quality Assurance (QA) tests, as well as the
need for establishing a standardized QA protocol. Future implications
and potential courses of research will also be discussed.
Συγγραφείς:
Chalkia, Marina
Kouloulias, Vassilis
Tousoulis, Dimitris and
Deftereos, Spyridon
Tsiachris, Dimitris
Vrachatis, Dimitrios and
Platoni, Kalliopi
Λέξεις-κλειδιά:
ventricular tachycardia; atrial fibrillation; cardiac arrhythmias;
radioablation; stereotactic radiotherapy; stereotactic body radiation
therapy; quality assurance; dosimetry; respiratory gating
DOI:
10.3390/biomedicines9101461
