Περίληψη:
Premature aging, as denoted by a reduced telomere length (TL), has been
observed in several chronic inflammatory diseases, such as obesity and
type 2 diabetes mellitus (T2DM). However, no study to date has addressed
the potential inflammatory influence of the gut-derived Gram-negative
bacterial fragments lipopolysaccharide, also referred to as endotoxin,
and its influence on TL in low-grade inflammatory states such as type 2
diabetes mellitus (T2DM). The current study therefore investigated the
influence of endotoxin and inflammatory factors on telomere length (TL)
in adults with (T2DM: n = 387) and without (non-diabetic (ND) controls:
n = 417) obesity and T2DM. Anthropometric characteristics were taken,
and fasted blood samples were used to measure biomarkers, TL, and
endotoxin. The findings from this study highlighted across all
participants that circulating endotoxin (r = -0.17, p = 0.01) was
inversely associated with TL, noting that endotoxin and triglycerides
predicted 18% of the variance perceived in TL (p < 0.001). Further
stratification of the participants according to T2DM status and sex
highlighted that endotoxin significantly predicted 19% of the variance
denoted in TL among male T2DM participants (p = 0.007), where TL was
notably influenced. The influence on TL was not observed to be impacted
by anti-T2DM medications, statins, or anti-hypertensive therapies. Taken
together, these results show that TL attrition was inversely associated
with circulating endotoxin levels independent of the presence of T2DM
and other cardiometabolic factors, suggesting that low-grade chronic
inflammation may trigger premature biological aging. The findings
further highlight the clinical relevance of mitigating the levels of
circulating endotoxin (e.g., manipulation of gut microbiome) not only
for the prevention of chronic diseases but also to promote healthy
aging.
Συγγραφείς:
Al-Daghri, Nasser M.
Abdi, Saba
Sabico, Shaun
Alnaami,
Abdullah M.
Wani, Kaiser A.
Ansari, Mohammed G. A.
Khattak,
Malak Nawaz Khan
Khan, Nasiruddin
Tripathi, Gyanendra and
Chrousos, George P.
McTernan, Philip G.
