Τίτλος:
The Role of Circular RNAs in DNA Damage Response and Repair
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The role of non-coding RNA, and particularly of circular RNA, in the DNA
damage response and repair network is underappreciated. Given the vital
role of this network in preserving the genomic integrity and
consequently cellular homeostasis, the constantly increasing numbers of
discovered circular RNAs and the increasing implication of these
molecules in the function of this network unravel a new important field
that may open new therapeutic opportunities, but also require detailed
investigation.
Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs
that are abundantly expressed in the cell. CircRNAs have the capacity to
regulate gene expression by interacting with regulatory proteins and/or
other classes of RNAs. While a vast number of circRNAs have been
discovered, the majority still remains poorly characterized.
Particularly, there is no detailed information on the identity and
functional role of circRNAs that are transcribed from genes encoding
components of the DNA damage response and repair (DDRR) network. In this
article, we not only review the available published information on
DDRR-related circRNAs, but also conduct a bioinformatic analysis on data
obtained from public repositories to uncover deposited, yet
uncharacterized circRNAs derived from components of the DDRR network.
Finally, we interrogate for potential targets that are regulated by this
class of molecules and look into potential functional implications.
Συγγραφείς:
Papaspyropoulos, Angelos
Hazapis, Orsalia
Lagopati, Nefeli and
Polyzou, Aikaterini
Papanastasiou, Anastasios D.
Liontos,
Michalis
Gorgoulis, Vassilis G.
Kotsinas, Athanassios
Περιοδικό:
Blood cancer journal
Λέξεις-κλειδιά:
circRNA; double-strand breaks (DSB); DNA damage response and repair
(DDRR); tumorigenesis
DOI:
10.3390/cancers13215352
