Περίληψη:
Cutaneous squamous cell carcinoma (cSCC) is the second most common form
of skin cancer. National and international associations have issued
evidence- and consensus-based guidelines to offer clinicians a framework
to optimally manage patients with invasive cSCC. Current updated
guidelines regarding the recommendations on the management of patients
with high-risk and advanced cSCC include EDF/EADO (European) Guidelines
2020, US National Comprehensive Cancer Network guidelines 2021, American
Academy of Dermatology guidelines 2018, British Association of
Dermatology guidelines 2020 and German guidelines 2020. This review
presents the guideline recommendations on the definition of high-risk
and advanced cSCC, surgical treatment and safety margins, definitive and
adjuvant radiotherapy and systemic treatments. The recommendations
across guidelines may converge, diverge or in some cases not be able to
provide a recommendation, highlighting open questions to be answered by
future studies.
