Περίληψη:
Objective This study aimed to evaluate and quantify the relationship
between coffee and gastric cancer using a uniquely large dataset from an
international consortium of observational studies on gastric cancer,
including data from 18 studies, for a total of 8198 cases and 21 419
controls. Methods A two-stage approach was used to obtain the pooled
odds ratios (ORs) and the corresponding 95% confidence intervals (CIs)
for coffee drinkers versus never or rare drinkers. A one-stage logistic
mixed-effects model with a random intercept for each study was used to
estimate the dose-response relationship. Estimates were adjusted for
sex, age and the main recognized risk factors for gastric cancer.
Results Compared to never or rare coffee drinkers, the estimated pooled
OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of
coffee intake was considered, the pooled ORs were 0.91 (95% CI,
0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10)
for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR
of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven
or more cups of caffeinated coffee per day). A positive association
emerged for high coffee intake (five or more cups per day) for gastric
cardia cancer only. Conclusions These findings better quantify the
previously available evidence of the absence of a relevant association
between coffee consumption and gastric cancer.
Συγγραφείς:
Martimianaki, Georgia
Bertuccio, Paola
Alicandro, Gianfranco and
Pelucchi, Claudio
Bravi, Francesca
Carioli, Greta
Bonzi,
Rossella
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi and
Johnson, Ken
Hu, Jinfu
Palli, Domenico
Ferraroni, Monica and
Lunet, Nuno
Morais, Samantha
Tsugane, Shoichiro
Hidaka,
Akihisa
Hamada, Gerson Shigueaki
Lopez-Carrillo, Lizbeth and
Hernandez-Ramirez, Raul Ulises
Zaridze, David
Maximovitch,
Dmitry
Aragones, Nuria
Martin, Vicente
Ward, Mary H. and
Vioque, Jesus
Garcia de la Hera, Manoli
Zhang, Zuo-Feng and
Kurtz, Robert C.
Lagiou, Pagona
Lagiou, Areti
Trichopoulou,
Antonia
Karakatsani, Anna
Malekzadeh, Reza
Camargo, M.
Constanza
Curado, Maria Paula
Boccia, Stefania
Boffetta,
Paolo
Negri, Eva
La Vecchia, Carlo
