Τίτλος:
Asporin and knee osteoarthritis in patients of Greek origin
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Ostearthritis (OA) is characterized by focal areas of loss of the articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change and synovitis. The Asporin (ASPN) gene which encodes a protein of the extracellular cartilage matrix contains a triplet repeat encoding for aspartic acid (D) within exon 2 The D14 allele was found associated with knee and hip osteoarthritis in case-control study in the Japanese population. Genotyping Greek knee OA patients for the D repeats we determined that the D15 allele could be considered a risk allele for our population. © 2005 OsteoArthritis Research Society International.
Συγγραφείς:
Kaliakatsos, M.
Tzetis, M.
Kanavakis, E.
Fytili, P.
Chouliaras, G.
Karachalios, Th.
Malizos, K.
Tsezou, A.
Περιοδικό:
Osteoarthritis and Cartilage
Λέξεις-κλειδιά:
aspartic acid; asporin; scleroprotein; unclassified drug, adult; aged; allele; article; case control study; controlled study; female; gene frequency; genetic polymorphism; genetic risk; genetic susceptibility; genetic variability; Greece; high risk population; human; knee osteoarthritis; major clinical study; male; pathogenesis; priority journal; risk factor; total knee replacement, Aged; Aged, 80 and over; Carrier Proteins; Case-Control Studies; Extracellular Matrix Proteins; Female; Gene Frequency; Greece; Humans; Male; Middle Aged; Osteoarthritis, Knee; Polymorphism, Genetic; Risk Factors
DOI:
10.1016/j.joca.2005.10.012
