Τίτλος:
Presence of the bcr/abl rearrangement in a patient with chronic
neutrophilic leukaemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
An 83 year old woman presented with a myeloproliferative disorder
involving the myeloid and megakaryocytic lines, and characterised by
mature neutrophil leucocytosis. There was a high/normal neutrophil
alkaline phosphatase activity and absence of the Philadelphia
chromosome, features compatible with a diagnosis of chronic neutrophilic
leukaemia (CNL). Southern blot analysis of the patient’s DNA revealed
the presence of the bcr/abl rearrangement. Combined with a previous
report of detection of Ph(1) chromosome in long term bone marrow
cultures in a patient with CNL, this finding suggests that the bcr/abl
hybrid gene might occasionally result in a myeloproliferative disorder
with a phenotype closely resembling that of CNL.
Συγγραφείς:
Christopoulos, C
Kottoris, K
Mikraki, V
Anevlavis, E
Περιοδικό:
Journal of Clinical Pathology
Εκδότης:
BRITISH MED JOURNAL PUBL GROUP
Λέξεις-κλειδιά:
chronic neutrophilic leukaemia; myeloproliferative disorders; chronic
granulocytic leukaemia; bcr/abl rearrangement; Philadelphia chromosome
DOI:
10.1136/jcp.49.12.1013
