Περίληψη:
In female rats, aged 55-58 days with delayed puberty due to deficient
growth and environmental stress, 5-hydroxyindoleacetic acid levels and
serotonin turnover rate in the hypothalamus-preoptic area as well as
body weight, body weight gain and relative weight of ovaries, uterus,
adrenals and preputial glands were lower while serotonin and
5-hydroxyindoleacetic acid levels in the prefrontal cortex were higher
when compared to normal rats with the latest onset of puberty aged 42-52
days. In rats with delayed puberty, multiple regression analysis
revealed a significant negative dependence on dopamine turnover in the
hypothalamus-preoptic area for body weight gain and, of all organs, for
the relative weight of the thymus. A similar negative significant
dependence on serotonin turnover rate in the prefrontal cortex was also
found for the relative weight of thymus and spleen. The same analysis in
the opposite direction revealed a significant negative dependence of
3,4-dihydroxyphenylacetic acid levels and dopamine turnover rate in the
hypothalamus-preoptic area as well as serotonin turnover rate in the
prefrontal cortex only on thymus weight. After separation of delayed
pubertal rats into two groups, based on absolute ovarian weight, the
rats in the low ovarian weight range and no signs of puberty exhibited:
lower body weight gain, lower body weight, and lower relative weight
only of thymus, ovaries and preputial glands in parallel with an
increased dopamine turnover rate in the hypothalamus-preoptic area and
serotonin turnover rate in the prefrontal cortex compared to the delayed
pubertal rats in the high oval-lan weight range and early signs of
puberty. The results suggest that in rats with delayed puberty: (1)
serotonergic activation in the hypothalamus-preoptic area is lower
compared to normal puberty rats; (2) dopaminergic activation in the
hypothalamus-preoptic area negatively affects body weight gain, thymus
weight and initiation of puberty and (3) thymus weight is negatively
implicated in dopaminergic activation in the hypothalamus-preoptic area
and serotonergic activation in the prefrontal cortex and positively
related to ovarian weight and early signs of puberty, (C) 1997 ISDN.
Published by Elsevier Science Ltd.
Συγγραφείς:
Antoniou, K
Papadopoulou-Daifotis, Z
Kanelakis, K
Varonos,
DD
Sfikakis, A
