Περίληψη:
Objective. Most information available about the disease course of
patients with systemic lupus erythematosus (SLE) is restricted to the
first 5 yr after disease onset. Data about the disease course 10 yr
after disease onset are rare. The aim of this multicentre study was to
describe the outcome of SLE patients with a disease duration of >10 yr.
Methods. Outcome parameters were the SLE Disease Activity Index
(SLEDAI); the European Consensus Lupus Activity Measure (ECLAM), the
Systemic Lupus International Collaborative Clinics/American College of
Rheumatology Damage Index (SLICC/ACR), a global damage index (DI) and
required treatment. In 10 different European rheumatology centres, all
SLE patients who were evaluated in the last 3 months of 1994, and who
had been diagnosed with SLE at least 10 yr ago, were included in the
study.
Results. It should be stressed that our results are confined to a
patient cohort, defined by a disease duration of at least 10 yr, and who
are still under clinical care at the different centres in Europe. These
SLE patients still showed some disease activity, related to symptoms of
the skin and musculoskeletal systems, next to the presence of renal
involvement. A total of 72% of the patients needed treatment with
prednisolone (less than or equal to 7.5 mg). The cumulative damage was
overall related to clinical features of the central nervous system
(14%) and renal involvement (14%), next to deforming arthritis (14%),
osteoporosis (15%) and hypertension (40%). The prevalences of obesity,
Cushing appearance and diabetes are highly suggestive that the ongoing
treatment and that in the past might have had an impact on the total sum
of endorgan damage.
Conclusions. After 10 yr, a high proportion of patients in our cohort
continued to show evidence of active disease, defined by the SLEDAI as
well as ECLAM. The DI was related to the involvement of the central
nervous system, renal involvement and the presence of hypertension.
Συγγραφείς:
Swaak, AJG
van den Brink, HG
Smeenk, RJT
Manger, K and
Kalden, JR
Tosi, S
Marchesoni, A
Domljan, Z
Rozman, B
and Logar, D
Pokorny, G
Kovacs, L
Kovacs, A and
Vlachoyiannopoulos, PG
Moutsopoulos, HM
Chwalinska-Sadowska, H
and Dratwianka, B
Kiss, E
Cikes, N
Branimir, A and
Schneider, M
Fischer, R
Bombardieri, S
Mosca, M and
Graninger, W
Smolen, JS
