Περίληψη:
A novel biodegradable system of D-,L-dilactide delivering pefloxacin was
implanted in 104 rabbits with experimental osteomyelitis caused by
methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as
controls. Animals were killed on each third day and viable bacterial
counts and levels of pefloxacin in bone tissue were determined. A 99.9%
decrease in viable count of bacteria was achieved by day 12 and complete
bacterial eradication on day 33. Pefloxacin was released gradually,
reaching its peak on day 15 at levels 100 times the MIC of pefloxacin
for MRSA. The biodegradable system described may have a future role in
the therapeutic approach to osteomyelitis.
Συγγραφείς:
Kanellakopoulou, K
Galanakis, N
Giamarellos-Bourboulis, EJ and
Rifiotis, C
Papakostas, K
Andreopoulos, A
Dounis, E and
Karagianakos, P
Giamarellou, H
