Τίτλος:
Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Therapeutic targeting of tumor cells with drug nanocarriers relies upon successful interaction with membranes and efficient cell internalization. A further consideration is that engineered nanomaterials should not damage healthy tissues upon contact. A critical factor in this process is the external coating of drug delivery nanodevices. Using in silico, in vitro and in vivo studies, we show for the first time that magnetic nanoparticles coated with polyarabic acid have superior imaging, therapeutic, and biocompatibility properties. We demonstrate that polyarabic acid coating allows for efficient penetration of cell membranes and internalization into breast cancer cells. Polyarabic acid also allows reversible loading of the chemotherapeutic drug Doxorubicin, which upon release suppresses tumor growth in vivo in a mouse model of breast cancer. Furthermore, these nanomaterials provide in vivo contrasting properties, which directly compare with commercial gadolinium-based contrasting agents. Finally, we report excellent biocompatibility, as these nanomaterial cause minimal, if any cytotoxicity in vitro and in vivo. We thus propose that magnetic nanodevices coated with polyarabic acid offer a new avenue for theranostics efforts as efficient drug carriers, while providing excellent contrasting properties due to their ferrous magnetic core, which can help the future design of nanomaterials for cancer imaging and therapy. © 2017 The Author(s).
Συγγραφείς:
Patitsa, M.
Karathanou, K.
Kanaki, Z.
Tzioga, L.
Pippa, N.
Demetzos, C.
Verganelakis, D.A.
Cournia, Z.
Klinakis, A.
Περιοδικό:
Scientific Reports
Εκδότης:
Nature Publishing Group
Λέξεις-κλειδιά:
antineoplastic antibiotic; arabic acid; biocompatible coated material; doxorubicin; drug carrier; gum arabic; magnetite nanoparticle; polymer, animal; cell membrane; chemistry; conformation; drug delivery system; drug screening; human; molecular dynamics; molecular imaging; mouse; nuclear magnetic resonance imaging; procedures; theranostic nanomedicine; tumor cell line, Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Membrane; Coated Materials, Biocompatible; Doxorubicin; Drug Carriers; Drug Delivery Systems; Gum Arabic; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Molecular Conformation; Molecular Dynamics Simulation; Molecular Imaging; Polymers; Theranostic Nanomedicine; Xenograft Model Antitumor Assays
DOI:
10.1038/s41598-017-00836-y
