Περίληψη:
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels. © 2010 Informa UK Ltd.
Συγγραφείς:
Rundle, A.
Richie, J.
Steindorf, K.
Peluso, M.
Overvad, K.
Raaschou-Nielsen, O.
Clavel-Chapelon, F.
Linseisen, J.P.
Boeing, H.
Trichopoulou, A.
Palli, D.
Krogh, V.
Tumino, R.
Panico, S.
Bueno-De-Mesquita, H.B.
Peeters, P.H.
Lund, E.
Gonzalez, C.A.
Martinez, C.
Dorronsoro, M.
Barricarte, A.
Tormo, M.J.
Quiros, J.R.
Agudo, A.
Berglund, G.
Jarvholm, B.
Bingham, S.
Key, T.J.
Gormally, E.
Saracci, R.
Kaaks, R.
Riboli, E.
Vineis, P.
Λέξεις-κλειδιά:
biological marker; glutathione; hemoglobin; phosphorus 32, adult; aged; article; cancer risk; controlled study; DNA adduct; erythrocyte; female; human; leukocyte; lung cancer; major clinical study; male; molecular epidemiology; physical activity; smoking, Aged; Biological Markers; Case-Control Studies; DNA Adducts; Erythrocytes; Europe; Female; Glutathione; Humans; Leukocytes; Lung Neoplasms; Male; Middle Aged; Molecular Epidemiology; Motor Activity; Pilot Projects; Risk Factors; Smoking
