Τίτλος:
Antidepressants influence somatostatin levels and receptor pharmacology in brain
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This study investigated how the administration (acute and chronic) of the antidepressants citalopram and desmethylimipramine (DMI) influences somatostatin (somatotropin release inhibitory factor, SRIF) levels and SRIF receptor density (sst1-5) in rat brain. Animals received either of the following treatments: (1) saline for 21 days (control group), (2) saline for 20 days and citalopram or DMI for 1 day (citalopram or DMI acute groups), (3) citalopram or DMI for 21 days (citalopram or DMI chronic groups). Somatostatin levels were determined by radioimmunoassay. [125I]LTT SRIF-28 binding in the absence (labeling of sst1-5) or presence of 3 nM MK678 (labeling of sst1/4) and [125I]Tyr3 octreotide (labeling of sst2/5) binding with subsequent autoradiography was performed in brains of rats treated with both antidepressants. Somatostatin levels were increased after citalopram, but not DMI administration, in the caudate-putamen, hippocampus, nucleus accumbens, and prefrontal cortex. Autoradiography studies illustrated a significant decrease in receptor density in the superficial and deep layers of frontal cortex (sst2), as well as a significant increase in the CA1 (sst1/4) hippocampal field in brains of chronically citalopram-treated animals. DMI administration increased sst 1/4 receptors levels in the CA1 hippocampal region. These results suggest that citalopram and to a lesser extent DMI influence the function of the somatostatin system in brain regions involved in the emotional, motivational, and cognitive aspects of behavior. © 2009 Nature Publishing Group All rights reserved.
Συγγραφείς:
Pallis, E.
Vasilaki, A.
Fehlmann, D.
Kastellakis, A.
Hoyer, D.
Spyraki, C.
Thermos, K.
Περιοδικό:
European Neuropsychopharmacology
Λέξεις-κλειδιά:
citalopram; desipramine; somatostatin; somatostatin receptor, animal experiment; animal tissue; article; autoradiography; caudate nucleus; controlled study; drug receptor binding; frontal cortex; hippocampus; male; nonhuman; nucleus accumbens; prefrontal cortex; priority journal; putamen; radioimmunoassay; rat; receptor density, Analysis of Variance; Animals; Antidepressive Agents; Autoradiography; Brain; Citalopram; Desipramine; Immunoassay; Iodine Radioisotopes; Male; Octreotide; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Somatostatin
DOI:
10.1038/npp.2008.133
