Τίτλος:
Effect of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-α levels in rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-α is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-α in free-feeding rats. Methods: Three groups of male Wistar rats (n = 63) were fed a high-fat diet, high-carbohydrate diet or high-protein diet for 13 weeks. In the last 3 weeks, each group was divided into 3 subgroups. Each subgroup received sibutramine 5 mg/kg, sibutramine 10 mg/kg or vehicle. Food intake was measured daily during the last week of the experiment; serum TNF-α was assayed and the body weight increasing rate was calculated. Results: The high-fat diet was associated with increased food intake, a greater weight gain ratio and increased TNF-α levels. Sibutramine treatment did not affect the dietary behaviour of high-protein- or high-carbohydrate-fed rats, while it significantly attenuated the daily food intake and body weight gain rate in the high-fat group, at the dose of 10 mg/kg. TNF-α levels were not affected by sibutramine. Conclusions: High-fat feeding was associated with an increase in daily food intake, TNF-α levels and body weight gain rate, as well as with enhanced responsiveness to the anorectic effects of sibutramine. However, sibutramine did not affect TNF-α. Copyright © 2008 S. Karger AG.
Συγγραφείς:
Trapali, M.
Liapi, C.
Perelas, A.
Perrea, D.
Stroubini, T.
Dontas, I.
Couvari, E.
Mavri, M.
Galanopoulou, P.
Περιοδικό:
Pharmacological Research Communications
Λέξεις-κλειδιά:
sibutramine; tumor necrosis factor alpha, animal experiment; article; body mass; body weight; caloric intake; carbohydrate diet; controlled study; drug effect; food intake; lipid diet; male; nonhuman; priority journal; protein diet; rat; weight gain, Animals; Appetite Depressants; Body Weight; Cyclobutanes; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Eating; Energy Intake; Enzyme-Linked Immunosorbent Assay; Feeding Behavior; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Weight Gain
