Τίτλος:
A simple method for the alkaline hydrolysis of esters
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed. © 2007 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Theodorou, V.
Skobridis, K.
Tzakos, A.G.
Ragoussis, V.
Περιοδικό:
TETRAHEDRON LETTERS
Λέξεις-κλειδιά:
alcohol derivative; carboxylic acid; dichloromethane; ester; ester derivative; methanol; sodium hydroxide; solvent, alkalinity; article; drug synthesis; hydrolysis; nonaqueous phase liquid; organic chemistry; process development; reaction analysis; room temperature; saponification; stereochemistry; temperature dependence
DOI:
10.1016/j.tetlet.2007.09.074
