Τίτλος:
Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities. © 2007 by MDPI.
Συγγραφείς:
Naoum, F.
Kasiotis, K.M.
Magiatis, P.
Haroutounian, S.A.
Περιοδικό:
Molecules (Basel, Switzerland)
Λέξεις-κλειδιά:
estrogen receptor alpha; estrogen receptor beta; ligand; nitro derivative; pyrazole; pyrazole derivative, article; chemistry; human; metabolism; synthesis, Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Ligands; Nitro Compounds; Pyrazoles
