Τίτλος:
Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P-hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease - an enzyme which is a medicinally relevant molecular target. The inhibitory potency of compounds was validated using enzyme purified from Bacillus pasteurii. © ARKAT-USA, Inc.
Συγγραφείς:
Vassiliou, S.
Grabowiecka, A.
Kosikowska, P.
Berlicki, L.
Περιοδικό:
ARKIVOC: Online Journal of Organic Chemistry
DOI:
10.3998/ark.5550190.0013.404