Τίτλος:
Polycystic οvary syndrome revisited: An interactions network approach
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The polycystic ovary syndrome (PCOS) has genetic, epigenetic, metabolic and reproductive aspects, while its complex pathophysiology has not been conclusively deciphered. Aim: The goal of this research was to screen the gene/gene products associated with PCOS and to predict any possible interactions with the highest possible fidelity. Materials and Methods: STRING v10.5 database and a confidence level of 0.7 were used. Results: A highly interconnected network of 48 nodes was created, where insulin (INS) appears to be the major hub. INS upstream and downstream defects were analysed and revealed that only the kisspeptin- and glucagon-coding genes were upstream of INS. Conclusion: A metabolic dominance was inferred and discussed herein with its implications in puberty, obesity, infertility and cardiovascular function. This study, thus, may contribute to the resolution of a scientific conflict between the USA and EU definitions of the syndrome and/or provide a new P4 medicine approach. © 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd
Συγγραφείς:
Geronikolou, S.A.
Pavlopoulou, A.
Cokkinos, D.V.
Bacopoulou, F.
Chrousos, G.P.
Περιοδικό:
European Journal of Clinical Investigation
Εκδότης:
John Wiley and Sons Inc
Λέξεις-κλειδιά:
aldo keto reductase family 1 member C3; alpha ketoglutarate dependent dioxygenase FTO; androgen receptor; angiotensin converting enzyme 2; angiotensinogen; argipressin; bone morphogenetic protein 15; calpain 10; cholecystokinin; cytochrome P450 family 17; cytochrome P450 family 19; cytochrome P450 family 21; cytokine; dalarelin; dipeptidyl carboxypeptidase; Fanconi anemia group C protein; follitropin beta subunit; ghrelin receptor; glucagon; glucose 6 phosphatase; glycoprotein; gonadorelin receptor; growth differentiation factor 9; insulin; insulin receptor; insulin receptor substrate 1; insulin receptor substrate 2; interleukin 1alpha; interleukin 1beta; interleukin 6; interleukin 8; Kiss1 receptor; kisspeptin; leptin; luteinizing hormone receptor; Muellerian inhibiting factor; nuclear receptor corepressor; peroxisome proliferator activated receptor gamma; serine proteinase inhibitor; sex hormone binding globulin; somatomedin B; somatomedin C; sulfotransferase; transcription factor 7 like 2; transcription factor GATA 4; transcription factor Yap1; tumor necrosis factor; vitamin D receptor, cardiovascular effect; chromosome 9; female; female infertility; gene product; genetic association; human; obesity; ovary polycystic disease; pathophysiology; predictive value; protein interaction; puberty; Review; thermoregulation; upregulation; cardiovascular disease; gene regulatory network; genetics; metabolism; ovary polycystic disease; protein analysis, Cardiovascular Diseases; Female; Gene Regulatory Networks; Humans; Infertility, Female; Obesity; Polycystic Ovary Syndrome; Protein Interaction Maps; Puberty
