Pathways and role of MALAT1 in esophageal and gastric cancer (Review)

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3076640 40 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Pathways and role of MALAT1 in esophageal and gastric cancer (Review)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Esophageal cancer (EC) and gastric cancer (GC) often have an unfavorable prognosis. Therefore, research is being conducted to identify the molecular mechanisms under‑ lying the tumorigenesis and progression of GC and EC, and to indicate novel therapeutic targets and clinically applicable biomarkers. The dysregulations and roles of long non‑coding RNAs (lncRNAs) have been widely reported, and current published literature has shown that lncRNAs play important regulatory roles in the carcinogenesis and progression of EC and GC. The lncRNA metastasis‑associated lung adeno‑ carcinoma transcript 1 (MALAT1) has been investigated in a number of studies with regard to its pathogenic pathways and association with the prognosis of gastric and esophageal malignancies. As literature on the topic of MALAT1 in EC and GC continues to emerge, the present review aims to summarize all current knowledge on the association between MALAT1 expression and esophagogastric malignancies and to describe the pathogenic pathways and possible prognostic role of MALAT1 in esophagogastric cancer. As research studies on MALAT1 pathways in esophagogastric malignan‑ cies are ongoing, new possibilities for the diagnosis, prognosis and therapy of GC and EC are likely to be identified. © 2021 Spandidos Publications. All rights reserved.
Έτος δημοσίευσης:
2021
Συγγραφείς:
Syllaios, A.
Moris, D.
Karachaliou, G.S.
Sakellariou, S.
Karavokyros, I.
Gazouli, M.
Schizas, D.
Περιοδικό:
Oncology Letters
Εκδότης:
Spandidos Publications
Τόμος:
21
Αριθμός / τεύχος:
5
Λέξεις-κλειδιά:
ATM protein; biological marker; checkpoint kinase 2; cyclin dependent kinase 1; focal adhesion kinase; high mobility group B2 protein; interleukin 21 receptor; long untranslated RNA; matrix metalloproteinase; metastasis associated lung adenocarcinoma transcript 1; microRNA; microRNA 101; nerve cell adhesion molecule; sirtuin 1; somatomedin C receptor; transcription factor EZH2; transcription factor Snail; transcription factor Sox2; unclassified drug; uvomorulin, apoptosis; cancer growth; cancer prognosis; carcinogenesis; cell cycle arrest; cell invasion; cell migration; cell proliferation; colony formation; disease free survival; down regulation; epithelial mesenchymal transition; esophageal adenocarcinoma; esophageal squamous cell carcinoma; esophagus cancer; gene overexpression; human; overall survival; Pi3K/Akt signaling; protein expression; Review; signal transduction; single nucleotide polymorphism; stomach cancer; tumor suppressor gene; tumor volume; upregulation
Επίσημο URL (Εκδότης):
DOI:
10.3892/ol.2021.12604
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