Τίτλος:
Prevention of gestational diabetes mellitus in overweight or obese pregnant women: A network meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: Several interventions have been implemented to prevent the development of gestational diabetes mellitus (GDM) in obese pregnant women, including physical exercise programs, and administration of metformin, vitamin D and probiotics. The aim of this network meta‐analysis was to compare the efficiency of these interventions and identify the optimal. Materials: A network meta-analysis of randomized trials was performed comparing the different interventions for the development of GDM in overweight or obese women, either to each other or placebo/no intervention. A search was conducted in four electronic databases and grey literature sources. The primary outcome was the development of GDM; secondary outcomes were other complications of pregnancy. Results: The meta-analysis included 23 studies (4237 participants). None of the interventions was superior compared with placebo/no intervention for the prevention of GDM. Metformin and physical exercise were superior to placebo/no intervention for gestational weight gain (MD −1.21, 95% CI −2.14 to −0.28 and MD −0.96, 95% CI −1.69 to −0.22, respectively). Metformin was superior to placebo/no intervention for caesarean sections and admission to NICU. Conclusions: Interventions aiming to prevent the development of GDM in overweight/obese women are not effective, when applied during pregnancy. © 2019 Elsevier B.V.
Συγγραφείς:
Chatzakis, C.
Goulis, D.G.
Mareti, E.
Eleftheriades, M.
Zavlanos, A.
Dinas, K.
Sotiriadis, A.
Περιοδικό:
Diabetes Research and Clinical Practice
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
metformin, cesarean section; clinical outcome; comparative effectiveness; disease course; exercise; female; gestational weight gain; human; intervention study; maternal obesity; meta analysis; neonatal intensive care unit; network meta-analysis; pregnancy complication; pregnancy diabetes mellitus; pregnant woman; prophylaxis; randomized controlled trial (topic); Review; adult; complication; network meta-analysis; obesity; pregnancy; pregnancy diabetes mellitus, Adult; Diabetes, Gestational; Female; Humans; Network Meta-Analysis; Obesity; Overweight; Pregnancy
DOI:
10.1016/j.diabres.2019.107924
