Τίτλος:
Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Disruption of tissue function activates cellular stress which triggers a number of mechanisms that protect the tissue from further damage. These mechanisms involve a number of homeostatic modules, which are regulated at the level of gene expression by the transactivator NF-κB. This transcription factor shifts between activation and repression of discrete, cell-dependent gene expression clusters. Some of its target genes provide feedback to NF-κB itself, thereby strengthening the inflammatory response of the tissue and later terminating inflammation to facilitate restoration of tissue homeostasis. Disruption of key feedback modules for NF-κB in certain cell types facilitates the survival of clones with genomic aberrations, and protects them from being recognized and eliminated by the immune system, to enable thereby carcinogenesis. © 2020, Springer Nature B.V.
Συγγραφείς:
Lambrou, G.I.
Hatziagapiou, K.
Vlahopoulos, S.
Περιοδικό:
Current Molecular Biology Reports
Λέξεις-κλειδιά:
cytokine; hormone; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; mitogen activated protein kinase; Myc protein; STAT3 protein; immunoglobulin enhancer binding protein, antiapoptosis; cancer growth; carcinogenesis; cell stress; cell survival; disease association; gene expression; homeostasis; human; immune system; inflammation; innate immunity; malignant neoplasm; nonhuman; oxidative stress; physiology; proapoptotic activity; protein function; Review; stress; tissue stress; animal; gene expression regulation; genetics; homeostasis; inflammation; metabolism, Animals; Gene Expression; Gene Expression Regulation; Homeostasis; Humans; Inflammation; NF-kappa B
DOI:
10.1007/s11033-020-05410-w
