Τίτλος:
Birth weight related blood concentrations of the neurotransmission amino acids glutamine plus glutamate, phenylalanine and tyrosine in full-term breastfed infants perinatally
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The amino acids glutamine plus glutamate, phenylalanine and tyrosine are implicated in neurotransmission. We aimed to evaluate these amino acid blood concentrations in full-term breastfed infants with different birth weight (BW) perinatally. Breastfed full-term infants (n = 6000, males 3000, females 3000) BW 2000-4000 g were divided into four equal groups. Both males and females Groups A, 2000-2500 g, B 2500-3000 g, C 3000-3500 g, D 3500-4000 g. Blood samples on Guthrie cards, were taken on the 3rd day of life and quantified via a liquid chromatography tandem mass spectrometry (LC-MS/MS) method. Glutamine plus glutamate mean values were found to be statistically significantly different between males vs. females in all the studied groups. The highest values were determined in both males and females in group D. Statistically significantly higher values of phenylalanine appeared in group D vs. other groups. Tyrosine mean values were calculated to be statistically significantly different in both sexes in group A compared to other groups. Differences of glutamine plus glutamate, phenylalanine and tyrosine levels among full-term newborns with different BW are presented for the first time in the literature. Newborns with BW 3000-4000 g are benefited by having higher concentrations of the mentioned neurotransmission related amino acids. Neonatal screening reference values for these amino acids in relation to BW could be established, not only for preterm and low BW infants but also for full-term newborns with BW >3000 g. © 2020 2020 Walter de Gruyter GmbH, Berlin/Boston.
Συγγραφείς:
Manta-Vogli, P.D.
Schulpis, K.H.
Loukas, Y.L.
Dotsikas, Y.
Περιοδικό:
Journal of Pediatric Endocrinology and Metabolism
Εκδότης:
De Gruyter Mouton
Λέξεις-κλειδιά:
glutamic acid; glutamine; phenylalanine; tyrosine; agents interacting with transmitter, hormone or drug receptors; amino acid; glutamic acid; glutamine; phenylalanine; tyrosine, amino acid blood level; Article; birth weight; breast feeding; controlled study; female; human; infant; liquid chromatography-mass spectrometry; male; neurotransmission; newborn; perinatal period; sex difference; blood; reference value; sexual characteristics, Amino Acids; Birth Weight; Breast Feeding; Female; Glutamic Acid; Glutamine; Humans; Infant, Newborn; Male; Neurotransmitter Agents; Phenylalanine; Reference Values; Sex Characteristics; Tyrosine
DOI:
10.1515/jpem-2019-0522
