Τίτλος:
Immunological Characteristics of Colitis Associated with Anti-CTLA-4 Antibody Therapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Anti-CTL4-A therapy is associated with development of colitis. We characterized ipilimumab-associated colitis in nine melanoma patients (6 male, mean age: 55.3-yrs). Median value for diarrhea grade was 2, number of ipilimumab doses 2, and interval since last administration 3-wks. Endoscopic characteristics resembled inflammatory bowel disease and histology revealed predominance of plasmacytes or CD4+ T-cells. We observed significant upregulation of Th1 and Th17 effector pathways (>10-fold increase for IFN-γmRNA, >5-fold for IL-17A, p < 0.01 vs. controls). Significant elevation of FoxP3 was also detected. In conclusion, ipilimumab administration results in elevations of effector lymphocytes and pro-inflammatory mediators in the gut lamina propria. © 2017 Taylor & Francis Group, LLC.
Συγγραφείς:
Bamias, G.
Delladetsima, I.
Perdiki, M.
Siakavellas, S.I.
Goukos, D.
Papatheodoridis, G.V.
Daikos, G.L.
Gogas, H.
Περιοδικό:
Cancer Investigation
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
budesonide; corticosteroid; gamma interferon; infliximab; interleukin 10; interleukin 13; interleukin 17; interleukin 4; ipilimumab; messenger RNA; steroid; transcription factor FOXP3; antineoplastic agent; autacoid; CTLA4 protein, human; cytotoxic T lymphocyte antigen 4; forkhead transcription factor; FOXP3 protein, human; gamma interferon; IFNG protein, human; IL17A protein, human; interleukin 17; ipilimumab; monoclonal antibody, abdominal pain; adult; aged; Article; cancer immunotherapy; CD4+ T lymphocyte; clinical article; colonoscopy; controlled study; diarrhea; enterocolitis; female; fever; gene expression; histology; human; human tissue; lamina propria; male; metastatic melanoma; observational study; phenotype; plasma cell; priority journal; rectum hemorrhage; retrospective study; sigmoidoscopy; treatment outcome; antagonists and inhibitors; biopsy; chemically induced; colitis; colon; diarrhea; drug administration; drug effects; genetics; immunology; intestine mucosa; melanoma; metabolism; middle aged; pathology; Skin Neoplasms; Th1 cell; Th17 cell; time factor, Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Biopsy; Colitis; Colon; Colonoscopy; CTLA-4 Antigen; Diarrhea; Drug Administration Schedule; Female; Forkhead Transcription Factors; Humans; Inflammation Mediators; Interferon-gamma; Interleukin-17; Intestinal Mucosa; Male; Melanoma; Middle Aged; Plasma Cells; Retrospective Studies; Skin Neoplasms; Th1 Cells; Th17 Cells; Time Factors
DOI:
10.1080/07357907.2017.1324032
