Τίτλος:
Mechanisms in endocrinology: Aging and anti-Aging: A combo- Endocrinology overview
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity. © 2017 European Society of Endocrinology Printed in Great Britain.
Συγγραφείς:
Diamanti-Kandarakis, E.
Dattilo, M.
Macut, D.
Duntas, L.
Gonos, E.S.
Goulis, D.G.
Gantenbein, C.K.
Kapetanou, M.
Koukkou, E.
Lambrinoudaki, I.
Michalaki, M.
Eftekhari-Nader, S.
Pasquali, R.
Peppa, M.
Tzanela, M.
Vassilatou, E.
Vryonidou, A.
Περιοδικό:
European Journal of Endocrinology
Εκδότης:
BioScientifica Ltd
Λέξεις-κλειδιά:
antioxidant; insulin; prasterone; prasterone sulfate; androgen; antidiabetic agent; antioxidant; gonadotropin; immunological adjuvant; prasterone; testosterone, aging; biological activity; breast cancer; circadian rhythm; diet; endocrine gland; endocrinology; fertility preservation; fluid balance; frailty; hormonal therapy; human; hyperandrogenism; hyperthyroidism; hypogonadism; hypothalamus hypophysis system; hypothyroidism; intervention study; ischemic heart disease; lifespan; longevity; menopause; negative feedback; nonhuman; ovarian reserve; oxidative stress; pathophysiology; priority journal; quality of life; Review; thrombosis; thyroid gland; aging; diet therapy; electrolyte balance; endocrine system; estrogen therapy; feedback system; female; hormone substitution; hyperthyroidism; hypogonadism; hypothyroidism; male; metabolism; non insulin dependent diabetes mellitus; oxidative stress; pancreas islet beta cell; personalized medicine; stem cell; stem cell transplantation, Adjuvants, Immunologic; Aging; Androgens; Antioxidants; Circadian Rhythm; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Diet Therapy; Endocrine System; Estrogen Replacement Therapy; Feedback, Physiological; Female; Fertility Preservation; Gonadotropins; Hormone Replacement Therapy; Humans; Hyperandrogenism; Hyperthyroidism; Hypoglycemic Agents; Hypogonadism; Hypothalamo-Hypophyseal System; Hypothyroidism; Insulin-Secreting Cells; Male; Menopause; Ovarian Reserve; Oxidative Stress; Precision Medicine; Quality of Life; Stem Cell Transplantation; Stem Cells; Testosterone; Thyroid Gland; Water-Electrolyte Balance
