Τίτλος:
Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Pulmonary endothelium dysfunction is a key characteristic of ARDS. The aim of this study was to investigate endothelium-derived markers, such as angiopoietin-2 (Ang-2) and endothelial cell-specific molecule-1 (endocan), at the vascular and alveolar compartments as outcome predictors in ARDS. Fifty-three consecutive ARDS patients were studied. The primary outcome was 28-day mortality. Secondary endpoints were days of unassisted ventilation and days with organ failure other than ARDS, during the 28-day study period. Nonsurvivors presented higher lung injury scores and epithelial lining fluid (ELF) Ang-2 levels compared to survivors, with no significant differences in plasma Ang-2, endocan, and protein C concentrations between the two groups. In logistic regression analysis, ELF Ang-2 levels > 705 pg/ml were the only independent variable for 28-day mortality among the previous four. Plasma endocan values > 13 ng/pg were the only parameter predictive against days of unassisted ventilation during the 28-day study period. Finally, lung injury score > 2.25 and ELF Ang-2 levels > 705 pg/ml were associated with increased number of days with organ failure, other than ARDS. Our findings suggest that Ang-2 levels are increased in the alveolar compartment of ARDS patients, and this may be associated both with increased mortality and organ failure besides lung. © 2017 Iraklis Tsangaris et al.
Συγγραφείς:
Tsangaris, I.
Tsantes, A.
Vrigkou, E.
Kopterides, P.
Pelekanou, A.
Zerva, K.
Antonakos, G.
Konstantonis, D.
Mavrou, I.
Tsaknis, G.
Kyriazopoulou, E.
Mouktaroudi, M.
Kokori, S.
Orfanos, S.E.
Giamarellos-Bourboulis, E.J.
Armaganidis, A.
Περιοδικό:
Disease Markers
Λέξεις-κλειδιά:
angiopoietin 2; biological marker; endocan; plasminogen activator inhibitor 1; protein C; proteoglycan; unclassified drug; angiopoietin 2; biological marker; C reactive protein; ESM1 protein, human; proteoglycan; tumor protein, adult; adult respiratory distress syndrome; Article; artificial ventilation; clinical outcome; cohort analysis; controlled study; correlation analysis; epithelial lining fluid; female; Greece; human; independent variable; limit of detection; logistic regression analysis; lung alveolus; lung injury; lung ventilation; major clinical study; male; middle aged; mortality; multiple organ failure; observational study; predictive value; prognosis; prospective study; protein blood level; receiver operating characteristic; adult respiratory distress syndrome; aged; artificial ventilation; blood; metabolism, Aged; Angiopoietin-2; Biomarkers; C-Reactive Protein; Female; Humans; Male; Middle Aged; Neoplasm Proteins; Proteoglycans; Respiration, Artificial; Respiratory Distress Syndrome, Adult
DOI:
10.1155/2017/6758721
