Τίτλος:
The amount and duration of smoking is associated with aggravation of hormone and biochemical profile in women with PCOS
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We investigated the association between the amount and duration of smoking on biochemical, clinical parameters and the ovarian morphology in women with polycystic ovary syndrome (PCOS). That was a retrospective study. These women were divided into two groups, non-smokers (217) and smokers (92). The amount of cigarettes and duration of smoking was measured in pack-years. Both groups underwent clinical evaluation, biochemical and hormone analysis, transvaginal ultrasound and oral glucose tolerance tests (OGTT). The mean value of the number of cigarettes was 14.8 (±8.8) and the median value of pack-years in the smokers group was 4.0 (1.5-7.5). Smokers group has significantly higher free testosterone (F-T), 17-hydroxyprogesterone (17-OHP), delta 4 androstenedione (Δ4-A), T4, low-density lipoprotein (LDL), and white blood cells (WBC). During correlation of all the above parameters and pack-years, there has been significant positive correlation in F-T and Δ4-A. The participants with more pack-years showed statistically higher values of F-T and Δ4-A. There was also a significant positive correlation between total cholesterol, triglycerides, WBC and pack-years of the participants. Prolactin (PRL) has been inversely associated with pack-years. We concluded that the increase of pack-years aggravated lipid profile, WBC and decreased PRL levels, in PCOS patients. © 2015 Taylor & Francis.
Συγγραφείς:
Xirofotos, D.
Trakakis, E.
Peppa, M.
Chrelias, C.
Panagopoulos, P.
Christodoulaki, C.
Sioutis, D.
Kassanos, D.
Περιοδικό:
Gynecological Endocrinology
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
androstenedione; cholesterol; hormone; low density lipoprotein; prolactin; testosterone; triacylglycerol, adult; Article; biochemical analysis; cholesterol blood level; clinical evaluation; controlled study; disease association; female; Greek (people); hormone determination; human; leukocyte; lipoprotein blood level; major clinical study; middle aged; morphology; oral glucose tolerance test; ovary polycystic disease; priority journal; progesterone blood level; prolactin blood level; retrospective study; smoking; testosterone blood level; transvaginal echography; triacylglycerol blood level; adverse effects; blood; ovary polycystic disease; smoking; young adult, Adult; Female; Humans; Polycystic Ovary Syndrome; Retrospective Studies; Smoking; Young Adult
DOI:
10.3109/09513590.2015.1101440
