Τίτλος:
CORL expression and function in insulin producing neurons reversibly influences adult longevity in Drosophila
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals. © 2018 Tran et al.
Συγγραφείς:
Tran, N.L.
Goldsmith, S.L.
Dimitriadou, A.
Takaesu, N.T.
Consoulas, C.
Newfeld, S.J.
Περιοδικό:
G3: Genes, Genomes, Genetics
Εκδότης:
Genetics Society of America
Λέξεις-κλειδιά:
corl protein; genomic DNA; insect protein; insulin; unclassified drug; Drosophila protein; insulin, adult; Article; brain nerve cell; controlled study; corl reporter gene; Drosophila; female; insulin signaling; larva; lifespan; longevity; male; mating; nonhuman; null allele; protein function; reporter gene; animal; biosynthesis; cytology; Drosophila melanogaster; gene expression regulation; longevity; metabolism; nerve cell; nerve cell network; neurosecretion; physiology, Animals; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression Regulation; Insulin; Longevity; Male; Nerve Net; Neurons; Neurosecretion
DOI:
10.1534/g3.118.200572
