Τίτλος:
Osteopontin in relation to Prognosis following Coronary Artery Bypass Graft Surgery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Cardiovascular events may occur even after complete revascularization in patients with coronary artery disease. We measured preoperative osteopontin (OPN) levels in 131 consecutive patients (66.5 ± 10 years old, 117 men and 14 women) with left ventricular ejection fraction of 50.7 ± 9.2 % and low logistic EuroScore (3.5 ± 3.2 %) undergoing elective Coronary Artery Bypass Grafting (CABG) surgery. Patients were prospectively followed up for a median of 12 months (range 11-24). The primary study endpoint was the composite of cardiovascular death, nonfatal myocardial infarction, need for repeat revascularization, and hospitalization for cardiovascular events. Pre-op OPN plasma levels were 77.9 (49.5, 150.9). Patients with prior acute myocardial infarction (AMI) had significantly higher OPN levels compared to those without [131.5 (52.2, 219) versus 73.3 (45.1, 125), p = 0.007 ]. OPN levels were positively related to EuroScore (r = 0.2, p = 0.031). Pre-op OPN levels did not differ between patients who had a major adverse event during follow-up compared to those with no event (p = 0.209) and had no effect on the hazard of future adverse cardiac events [HR (95% CI): 1.48 (0.43-4.99), p = 0.527 ]. The history of AMI was associated with increased risk of subsequent cardiovascular events at follow-up (p = 0.02). OPN is associated with preoperative risk assessment prior to low-risk CABG but did not independently predict outcome. © 2016 Eftihia Sbarouni et al.
Συγγραφείς:
Sbarouni, E.
Georgiadou, P.
Chatzikyriakou, S.
Analitis, A.
Chaidaroglou, A.
Degiannis, D.
Voudris, V.
Περιοδικό:
Disease Markers
Λέξεις-κλειδιά:
osteopontin; biological marker; osteopontin, aged; Article; biochemical analysis; cardiovascular mortality; cardiovascular risk; coronary artery bypass graft; EuroSCORE; female; follow up; heart infarction; heart left ventricle ejection fraction; hospitalization; human; low risk patient; major clinical study; male; prevalence; prognosis; protein blood level; protein expression; risk assessment; blood; heart infarction; middle aged, Aged; Biomarkers; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Myocardial Infarction; Osteopontin
DOI:
10.1155/2016/1868739
