Περίληψη:
Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins. © 2015, Springer Science+Business Media New York.
Συγγραφείς:
Cournia, Z.
Allen, T.W.
Andricioaei, I.
Antonny, B.
Baum, D.
Brannigan, G.
Buchete, N.-V.
Deckman, J.T.
Delemotte, L.
del Val, C.
Friedman, R.
Gkeka, P.
Hege, H.-C.
Hénin, J.
Kasimova, M.A.
Kolocouris, A.
Klein, M.L.
Khalid, S.
Lemieux, M.J.
Lindow, N.
Roy, M.
Selent, J.
Tarek, M.
Tofoleanu, F.
Vanni, S.
Urban, S.
Wales, D.J.
Smith, J.C.
Bondar, A.-N.
Λέξεις-κλειδιά:
4 aminobutyric acid A receptor; amyloid; amyloid beta protein; cholesterol; G protein coupled receptor; ion channel; ligand gated ion channel; lipid; membrane protein; nicotinic receptor; phosphatidylinositol; proteinase; rhomboid protease; sphingomyelin; translocon; unclassified drug; water; carrier protein, Alzheimer disease; bacterial membrane; cell organelle; conformation; drug design; dynamics; Escherichia coli; experimental study; general device; lipid membrane; membrane transport; molecular dynamics; non insulin dependent diabetes mellitus; nonhuman; oligomerization; Parkinson disease; protein assembly; protein degradation; protein function; protein lipid interaction; protein structure; Review; voltage sensor domain; animal; biological model; chemical model; chemistry; genetics; human; metabolism; protein tertiary structure; structure activity relation, Animals; Humans; Membrane Transport Proteins; Models, Biological; Models, Chemical; Protein Structure, Tertiary; Structure-Activity Relationship
