Τίτλος:
Polymorphisms of uridine glucuronosyltransferase gene and irinotecan toxicity: Low dose does not protect from toxicity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Uridine glucuronosyltransferase (UGT) gene polymorphisms have been linked to irinotecan toxicity. Our purpose was to study the association between UGT1A1*28, UGT1A7*2, and UGT1A7*3 polymorphisms and irinotecan toxicity in Greek patients receiving low-dose weekly irinotecan. Blood samples were collected for 46 patients. DNA was extracted and UGT1A1 promoter and UGT1A7 exon 1 genotyping was carried out. Laboratory tests and physical examination were performed on regular basis for the assessment of toxicity. UGT1A1*28 was significantly correlated with both haematologic and non-haematologic toxicity. Moreover, patients carrying UGT1A7 polymorphisms had significant incidence of toxicity. To conclude, UGT polymorphisms play a role in the toxicity of irinotecan, even if the drug is administered in low doses. The genotyping test may be a useful tool for the management of patients who are going to receive irinotecan. © the authors; licensee ecancermedicalscience.
Συγγραφείς:
Tziotou, M.
Kalotychou, V.
Ntokou, A.
Tzanetea, R.
Armenis, I.
Varsou, M.
Konstantopoulos, K.
Tsavaris, N.
Rombos, Y.
Περιοδικό:
ecancermedicalscience
Εκδότης:
European Institute of Oncology
Λέξεις-κλειδιά:
DNA; fluorouracil; folinic acid; glucuronosyltransferase 1A1; glucuronosyltransferase 1A7; irinotecan; uridine, adult; aged; anemia; article; blood sampling; clinical article; diarrhea; drug dose reduction; drug withdrawal; exon; febrile neutropenia; female; gene; genetic polymorphism; genotype; Greece; human; laboratory test; leukopenia; low drug dose; male; metastatic colorectal cancer; middle aged; nausea; neutropenia; physical examination; promoter region; thrombocytopenia; vomiting
DOI:
10.3332/ecancer.2014.428
