Τίτλος:
The hypothalamic-pituitary-adrenal axis in women with differentiated thyroid cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction. We studied the function of hypothalamic-pituitary-adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk. Methods and Results. Sixteen women were investigated with (1) morning, evening, and midnight cortisol and adrenocortophic hormone, (2) cortisol after overnight 1 mg dexamethasone suppression test, (3) cortisol after corticotropin releasing hormone test, (4) oral glucose tolerance test with glucose and insulin estimations, and (5) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls. Conclusion. Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls. © 2010 Informa UK, Ltd.
Συγγραφείς:
Chrisoulidou, A.
Pazaitou-Panayiotou, K.
Georgiou, E.
Boudina, M.
Lytras, K.
Iakovou, I.
Vainas, I.
Kaltsas, G.
Περιοδικό:
Endocrine Research
Λέξεις-κλειδιά:
corticotropin; dexamethasone; glucose; insulin, adult; artery intima; article; cardiovascular risk; carotid artery; clinical article; controlled study; corticotropin blood level; corticotropin test; dexamethasone suppression test; female; glucose blood level; human; hydrocortisone blood level; hypothalamus hypophysis adrenal system; insulin blood level; insulin sensitivity; oral glucose tolerance test; priority journal; thyroid cancer, Adrenocorticotropic Hormone; Adult; Blood Glucose; Cardiovascular Diseases; Circadian Rhythm; Corticotropin-Releasing Hormone; Dexamethasone; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Insulin; Insulin Resistance; Lipids; Middle Aged; Pituitary-Adrenal System; Thyroid Neoplasms
DOI:
10.3109/07435800.2010.496760
