Περίληψη:
Background and Study Aims: Many factors, such as oxygen and vasculature,
are involved in the cytotoxic effect of photodynamic therapy (PDT). It
is known that somatostatin and its analog octreotide decrease the
splanchnic blood flow and have multiple inhibitory effects in different
functions of the peptic system. The aim of this experimental study was
to assess the effect of octreotide administration on PDT outcome in
normal pig stomach.
Methods: 28 healthy pigs, randomly assigned to two groups, A and B, were
studied. Pigs in both groups were sensitized with 0.3 mg/kg intravenous
meta-tetra (hydroxyphenyl) chlorin (mTHPC), and 48 hours later light of
wavelength 650 nm was delivered from a 50-mW diode laser for 300 s
(energy fluence 15 J/ cm(2)) through a gastroscope to the gastric
mucosa. Group A underwent PDT without octreotide and group B had PDT
with administration of octreotide. At 72 h after light delivery, all the
animals were sacrificed for macroscopic and histological evaluation of
the irradiated site.
Results: The macroscopic images and the histology of the stomach PDT
lesions (inflammation, ulceration, necrosis) showed significantly less
severity in the group of animals with octreotide injection (group B). In
this group, full-thickness necrosis was observed in 28.5 %, compared
with over 71.4 % in group A; this was statistically significant (P<
0.05).
Conclusion: Octreotide may have a modulating effect on mTPHC PDT in
normal gastric tissue in pigs, probably due to alterations of
hemodynamics in the stomach and to suppression of the inflammatory
process.
Συγγραφείς:
Mallas, E
Karamanolis, G
Zissis, M
Karvouni, E and
Kostopanagiotou, G
Macropoulou, M
Serafetinidis, AA
Ladas, S
and Raptis, SA
