Statin use and the risk of prostate cancer: A metaanalysis of 6 randomized clinical trials and 13 observational studies

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3094551 6 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Statin use and the risk of prostate cancer: A metaanalysis of 6 randomized clinical trials and 13 observational studies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Statins have been suggested to prevent prostate cancer. Our aim was to examine statin use in relation to both total prostate cancer and the more clinically important advanced prostate cancer, through a detailed metaanalysis of the epidemiologic studies published on the subject in peer-reviewed literature. A comprehensive search for articles published up to November 2007 was performed, reviews of each study were conducted and data were abstracted. Prior to metaanalysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using the random-effects model. Subgroup and sensitivity analyses were also performed. Nineteen studies [6 randomized clinical trials (RCTs), 6 cohort and 7 case-control studies] contributed to the analysis. There was no evidence of an association between statin use and total prostate cancer among either RCTs (RR = 1.06, 95% CI: 0.93-1.20) or the observational studies (RR = 0.89, 95% CI: 0.65-1.24). However, high heterogeneity was detected among the observational studies. Moreover, long-term statin use did not significantly affect the risk of total prostate cancer (RR = 0.93, 95% CI: 0.77-1.13). In contrast, synthesis of the available reports that had specifically examined statin use in relation to advanced prostate cancer indicated a protective association (RR = 0.77, 95% CI: 0.64-0.93). Our results do not support the hypothesis that statins reduce the risk of total prostate cancer. However, further research is required to investigate whether the particular association of statin use with lower risk of advanced prostate cancer is indeed causal. © 2008 Wiley-Liss, Inc.
Έτος δημοσίευσης:
2008
Συγγραφείς:
Bonovas, S.
Filioussi, K.
Sitaras, N.M.
Περιοδικό:
International Journal of Cancer
Τόμος:
123
Αριθμός / τεύχος:
4
Σελίδες:
899-904
Λέξεις-κλειδιά:
atorvastatin; cerivastatin; compactin; fluindostatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; mevinolin; pravastatin; rosuvastatin; simvastatin; hydroxymethylglutaryl coenzyme A reductase inhibitor, article; cancer risk; case control study; clinical trial; cohort analysis; confidence interval; controlled clinical trial; controlled study; human; long term care; major clinical study; male; meta analysis; multicenter study; observational study; priority journal; prostate cancer; randomized controlled trial; risk factor; sensitivity analysis; statistical significance; systematic review; incidence; prostate tumor, Cohort Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Risk Factors
Επίσημο URL (Εκδότης):
DOI:
10.1002/ijc.23550
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