Περίληψη:
Galanin has been found in increased amounts in subjects with type 2 diabetes. The purpose of the present study was to determine the levels of galanin in healthy volunteers during an oral glucose tolerance test (OGTT). We enrolled 11 healthy volunteers, 4 males aged 48±3.56 years with BMI 27±0.5 kg/m2 and 7 females aged 41.3±3.05 years with BMI 27.6±0.9 kg/m2. All were in good health without cardiac, hepatic, renal or other chronic disease. None were taking any medication affecting glucose tolerance (β-blockers, thiazide diuretics, and corticoids) and none had a first degree relative with type 2 diabetes. Glucose tolerance was determined by using the International Expert Committee criteria. Blood samples were collected at 0, 30, 60, 90, 120 and 180 minutes for the measurement of plasma glucose, insulin, C-peptide and human galanin (hGal). During the OGTT, hGal exhibited a significant increase from time 0 to 90 minutes (p < 0.001) and returned to the basal values at 180 minutes, while a positive correlation of blood glucose with hGal was observed during the time scale of OGTT. A significant increase was detected both in insulin and C-peptide from the early beginning of the test at 30 minutes, which remained steady until 90 minutes, and returned gradually to the basal values at 180 minutes. No relationship was found either between hGal and serum insulin, or between hGal and serum C-peptide among the healthy subjects, during the OGTT. © Georg Thieme Verlag KG Stuttgart.
Συγγραφείς:
Legakis, I.N.
Mantzouridis, T.
Mountokalakis, T.
Λέξεις-κλειδιά:
beta adrenergic receptor blocking agent; C peptide; corticosteroid derivative; galanin; glucose; insulin; thiazide diuretic agent; C peptide; galanin; insulin, adult; article; blood sampling; body mass; controlled study; female; glucose blood level; glucose tolerance; human; insulin blood level; male; normal human; oral glucose tolerance test; priority journal; blood; glucose blood level; glucose tolerance test; health, Adult; Blood Glucose; C-Peptide; Female; Galanin; Glucose Tolerance Test; Health; Humans; Insulin; Male
