Τίτλος:
Moc-31, fibronectin and CEA in the differential diagnosis of malignant effusions: An immunocytochemical study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In discriminating benign and malignant origins of cytologically suspicious effusion smears a panel of antibodies against carcinoembryonic antigen (CEA), Fibronectin (F) and MOC-31 was used with immunocytochemical techniques. One hundred and thirty seven effusions were studied of which 107 had a malignant and 30 a benign aetiology as determined by clinical and histological examination. Cytologically 24 were diagnosed as benign, 97 as malignant and 14 as suspicious. Staining for F was positive in all effusions of benign and 3 of malignant origin. MOC-31 was positive in 95 (88.8%) of effusions of malignant origin but none of benign origin. Positive CEA was observed in 43% of effusions of malignant origin and in 10 of benign origin. The combination of MOC-31 positivity measured the sensitivity and specificity of the cytological examination in cases where the cytological examination result was suspicious as did F positivity improve the sensitivity for a benign origin of the effusion. Positivity or negativity for CEA is less valuable than the other parameters.
Συγγραφείς:
Athanassiadou, P.
Gonidi, M.
Liossi, A.
Petrakakou, E.
Nakopoulou, L.
Zerva, C.
Athanassiades, P.
Περιοδικό:
Pathology and Oncology Research
Εκδότης:
Kluwer Academic Publishers
Λέξεις-κλειδιά:
antibody; carcinoembryonic antigen; fibronectin; membrane protein, article; controlled study; effusion; human; immunocytochemistry; major clinical study; malignant neoplastic disease
