Περίληψη:
Certain skin disorders, such as contact dermatitis and chronic
urticaria, are characterized by inflammation involving mast cells and
worsen by stress. The underlying mechanism of this effect, however, is
not known. The skin appears to have the equivalent of a
hypothalamic-pituitary-ad renal (HPA) axis, including local expression
of corticotropin-releasing hormone (CRH) and its receptors (CRH-R). We
have reported that acute stress and intradermal administration of CRH
stimulate skin mast cells and increase vascular permeability through
CRH-R1 activation. In this study, we investigated the expression of
CRH-R1, the main CRH-R subtype in human skin, and the mast cell related
gene histidine decarboxylase (HDC), which regulates the production of
histamine, in normal and pathological skin biopsies. Quantitative real
time PCR revealed that chronic urticaria expresses high levels of CRH-R1
and HDC as compared to normal foreskin, breast skin and cultured human
keratinocytes. The lichen simplex samples had high expression of CRH-R1,
but low HDC. These results implicate CRH-R in chronic urticaria, which
is often exacerbated by stress.
Συγγραφείς:
Papadopoulou, N
Kalogeromitros, D
Staurianeas, NG
Tiblalexi,
D
Theoharides, TC
