Τίτλος:
Human herpesvirus 8 infection in hemodialysis patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The aim of the present study was to evaluate human
herpesvirus 8 (HHV-8) seroprevalence in Greek hemodialysis patients.
Patterns of change in HHV-8 serostatus (seroconversions and
seroreversions) over time were also evaluated.
Methods: Serum samples obtained from a cohort of 485 Greek hemodialysis
patients were tested for antibodies to HHV-8 by whole virus lysate
enzyme-linked immunosorbent assay, and reactive samples were confirmed
by means of the orf-73 enzyme-linked immunosorbent assay. HHV-8
seroprevalence at study entry and the incidence of seroreversions and
seroconversions per 100 person-years were estimated.
Results: The prevalence of HHV-8 antibodies in Greek hemodialysis
patients at enrollment was 7.2%. No univariate associations were
established between HHV-8 serostatus and patients’ characteristics.
Incidences of seroreversions and seroconversions were 16.4/100
person-years (95% confidence interval, 7.1 to 32.3) and 0.28/100
person-years (95% confidence interval, 0.03 to 1.02), respectively.
Patients 50 years and younger had an increased probability for
seroreversion to HHV-8 antibodies than patients older than 50 years
(log-rank test, P = 0.018).
Conclusion: We observed a fair number of seroreversions and a low
incidence of seroconversion to HHV-8 infection in hemodialysis patients
in Greece. Our data provide indirect evidence that HHV-8 transmission in
the hemodialysis setting is uncommon.
Συγγραφείς:
Zavitsanou, A
Sypsa, V
Petrodaskalaki, M
Psichogiou, M and
Katsoulidou, A
Boletis, J
Hadjiconstantinou, V
Karalis, D
and Kalapothaki, V
Hatzakis, A
Περιοδικό:
American Journal of Kidney Diseases
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
Λέξεις-κλειδιά:
human herpesvirus 8; hemodialysis (HD); cohort; seroconversion;
seroreversion
DOI:
10.1053/j.ajkd.2005.09.019
