Περίληψη:
The in vitro activity of tigecycline was compared with those of
benzylpenicillin, piperacillin + tazobactam, cefoxitin, imipenem,
metronidazole, clindamycin, and tetracycline against 249 Gram-negative
anaerobic bacteria (158 Bacteroides fragilis group, 27 non fragilis
Bacteroides spp., 44 Prevotella spp., and 20 miscellaneous), recently
isolated from 8 general hospitals in Athens, Greece. Overall tigecycline
MIC50 and MIC90 were 0.25 and 2 mg/L, respectively, whereas B. fragilis
group MICSO and MIC90 were 0.5 and 4 mg/L, respectively. In total, 93%
of the isolates were susceptible to tigecycline (MIC <= 4 mg/L) and no
high-level resistance (MIC >= 32 mg/L) was detected. In addition,
tigecycline exhibited good activity against metronidazole- and
tetracycline-resistant isolates (MIC90, 0.5 and 8 mg/L, respectively).
In summary, tigecycline exhibits good in vitro activity against
Gram-negative anaerobic bacteria isolated in Greece, as well as
stability to the most common occurring resistance mechanisms, attributes
that make this parenteral agent an attractive alternative for use
against infections involving these microorganisms. (c) 2006 Elsevier
Inc. All rights reserved.
Συγγραφείς:
Katsandri, Anastasia
Avlamis, Athina
Pantazatou, Angeliki and
Petrikkos, Georgios L.
Legakis, Nicholas J.
Papaparaskevas,
Joseph
Hellenic Study Grp Gram Negative
