Treatment of Multisystem Inflammatory Syndrome in Children

McArdle, A.J.; Vito, O.; Patel, H.; Seaby, E.G.; Shah, P.; Wilson, C.; Broderick, C.; Nijman, R.; Tremoulet, A.H.; Munblit, D.; Ulloa-Gutierrez, R.; Carter, M.J.; De, T.; Hoggart, C.; Whittaker, E.; Herberg, J.A.; Kaforou, M.; Cunnington, A.J.; Levin, M.; Vazquez, J.A.; Carmona, R.; Perez, L.; Rubinos, M.; Veliz, N.; Yori, S.; Haerynck, F.; Hoste, L.; Leal, I.A.; Da Silva, A.R.A.; Silva, A.E.A.; Barchik, A.; Barreiro, S.T.A.; Cochrane, N.; Teixeira, C.H.; Arauj, J.M.; Ossa, R.A.P.-D.L.; Vieira, C.S.; Dimitrova, A.; Ganeva, M.; Stefanov, S.; Telcharova-Mihaylovska, A.; Biggs, C.M.; Scuccimarri, R.; Withington, D.; Raul, B.B.; Ampuero, C.; Aravena, J.; Casanova, D.; Cruces, P.; Diaz, F.; Garcia-Salum, T.; Godoy, L.; Medina, R.A.; Galaz, G.V.; Avila-Aguero, M.L.; Brenes-Chacon, H.; Ivankovich-Escoto, G.; Yock-Corrales, A.; Badib, A.; Badreldin, K.; Elkhashab, Y.; Heshmat, H.; Heinonen, S.; Angoulvant, F.; Belot, A.; Ouldali, N.; Beske, F.; Heep, A.; Masjosthusmann, K.; Reiter, K.; Heuvel, I.V.D.; Both, U.V.; Agrafiotou, A.; Antachopoulos, C.; Eleftheriou, I.; Farmaki, E.; Fotis, L.; Kafetzis, D.; Lampidi, S.; Liakopoulou, T.; Maritsi, D.; Michailidou, E.; Milioudi, M.; Mparmpounaki, I.; Papadimitriou, E.; Papaevangelou, V.; Roilides, E.; Tsiatsiou, O.; Tsolas, G.; Tsolia, M.; Vantsi, P.; Pineda, L.Y.B.; Aguilar, K.L.B.; Quintero, E.M.C.; Ip, P.; Kwan, M.Y.W.; Kwok, J.; Lau, Y.L.; To, K.; Wong, J.S.C.; David, M.; Farkas, D.; Kalcakosz, S.; Szekeres, K.; Zsigmond, B.; Aslam, N.; Andreozzi, L.; Bianco, F.; Bucciarelli, V.; Buonsenso, D.; Cimaz, R.; D'Argenio, P.; Dellepiane, R.M.; Fabi, M.; Mastrolia, M.V.; Mauro, A.; Mazza, A.; Romani, L.; Simonini, G.; Tipo, V.; Valentini, P.; Verdoni, L.; Reel, B.; Pace, D.; Torpiano, P.; Flores, M.F.; Domínguez, M.G.; Vargas, A.L.G.; Hernandez, L.L.; Figueroa, R.P.M.; Gaxiola, G.P.; Valadez, J.; Klevberg, S.; Knudsen, P.K.; Maseide, P.H.; Carrera, J.M.; Castano, E.G.; Timana, C.A.D.; Leon, T.D.; Estripeaut, D.; Levy, J.; Norero, X.; Record, J.; Rojas-Bonilla, M.; Iramain, R.; Hernandez, R.; Huaman, G.; Munaico, M.; Peralta, C.; Seminario, D.; Yarleque, E.H.Z.; Gadzinska, J.; Mandziuk, J.; Okarska-Napierała, M.; Alacheva, Z.A.; Alexeeva, E.; Ananin, P.V.; Antsupova, M.; Bakradze, M.D.; Bobkova, P.; Borzakova, S.; Chashchina, I.L.; Fisenko, A.P.; Gautier, M.S.; Glazyrina, A.; Kondrikova, E.; Korobyants, E.; Korsunskiy, A.A.; Kovygina, K.; Krasnaya, E.; Kurbanova, S.; Kurdup, M.K.; Mamutova, A.V.; Mazankova, L.; Mitushin, I.L.; Nargizyan, A.; Orlova, Y.O.; Osmanov, I.M.; Polyakova, A.S.; Romanova, O.; Samitova, E.; Sologub, A.; Spiridonova, E.; Tepaev, R.F.; Tkacheva, A.A.; Yusupova, V.; Zholobova, E.; Grasa, C.D.; Segura, N.L.; Martinon-Torres, F.; Melendo, S.; Echevarria, A.M.; Guzman, J.M.M.; Argueta, J.R.P.; Rivero-Calle, I.; Riviere, J.; Rodriguez-Gonzalez, M.; Rojo, P.; Manubens, J.S.; Soler-Palacin, P.; Soriano-Arandes, A.; Tagarro, A.; Villaverde, S.; Altman, M.; Brodin, P.; Horne, A.; Palmblad, K.; Brotschi, B.; Sauteur, P.M.; Schmid, J.P.; Prader, S.; Relly, C.; Schlapbach, L.J.; Seiler, M.; Truck, J.; Wutz, D.; Ketharanathan, N.; Vermont, C.; Ozkan, E.A.; Erdeniz, E.H.; Borisova, G.; Boychenko, L.; Diudenko, N.; Kasiyan, O.; Katerynych, K.; Melnyk, K.; Miagka, N.; Teslenko, M.; Trykosh, M.; Volokha, A.; Akomolafe, T.; Al-Abadi, E.; Alders, N.; Avram, P.; Bamford, A.; Bank, M.; Roy, R.B.; Beattie, T.; Boleti, O.; Broad, J.; Carrol, E.D.; Chandran, A.; Cooper, H.; Davies, P.; Emonts, M.; Evans, C.; Fidler, K.; Foster, C.; Gong, C.; Gongrun, B.; Gonzalez, C.; Grandjean, L.; Grant, K.; Hacohen, Y.; Hall, J.; Hassell, J.; Hesketh, C.; Hewlett, J.; Hnieno, A.; Holt-Davis, H.; Hossain, A.; Hudson, L.D.; Johnson, M.; Johnson, S.; Jyothish, D.; Kampmann, B.; Kavirayani, A.; Kelly, D.; Kucera, F.; Langer, D.; Lillie, J.; Longbottom, K.; Lyall, H.; MacKdermott, N.; Maltby, S.; McLelland, T.; McMahon, A.-M.; Miller, D.; Morrison, Z.; Mosha, K.; Muller, J.; Myttaraki, E.; Nadel, S.; Osaghae, D.; Osman, F.; Ostrzewska, A.; Panthula, M.; Papachatzi, E.; Papadopoulou, C.; Penner, J.; Polandi, S.; Prendergast, A.J.; Ramnarayan, P.; Rhys-Evans, S.; Riordan, A.; Rodrigues, C.M.C.; Romaine, S.; Seddon, J.; Shingadia, D.; Srivastava, A.; Struik, S.; Taylor, A.; Taylor, A.; Taylor, A.; Tran, S.; Tudor-Williams, G.; Van Der Velden, F.; Ventilacion, L.; Wellman, P.A.; Yanney, M.P.; Yeung, S.; Badheka, A.; Badran, S.; Bailey, D.M.; Burch, A.K.; Burns, J.C.; Cichon, C.; Cirks, B.; Dallman, M.D.; Delany, D.R.; Fairchok, M.; Friedman, S.; Geracht, J.; Langs-Barlow, A.; Mann, K.; Padhye, A.; Quade, A.; Ramirez, K.A.; Rockett, J.; Sayed, I.A.; Shahin, A.A.; Umaru, S.; Widener, R.; Angela, M.H.; Kandawasvika, G.; BATS Consortium

doi:10.1056/NEJMoa2102968

Μονάδα:

Ερευνητικό υλικό ΕΚΠΑ

Τίτλος:

Treatment of Multisystem Inflammatory Syndrome in Children

Γλώσσες Τεκμηρίου:

Αγγλικά

Περίληψη:

BACKGROUND Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS We performed an international observational cohort study of clinical and outcome data regarding suspected MIS-C that had been uploaded by physicians onto a Web-based database. We used inverse-probability weighting and generalized linear models to evaluate intravenous immune globulin (IVIG) as a reference, as compared with IVIG plus glucocorticoids and glucocorticoids alone. There were two primary outcomes: the first was a composite of inotropic support or mechanical ventilation by day 2 or later or death; the second was a reduction in disease severity on an ordinal scale by day 2. Secondary outcomes included treatment escalation and the time until a reduction in organ failure and inflammation. RESULTS Data were available regarding the course of treatment for 614 children from 32 countries from June 2020 through February 2021; 490 met the World Health Organization criteria for MIS-C. Of the 614 children with suspected MIS-C, 246 received primary treatment with IVIG alone, 208 with IVIG plus glucocorticoids, and 99 with glucocorticoids alone; 22 children received other treatment combinations, including biologic agents, and 39 received no immunomodulatory therapy. Receipt of inotropic or ventilatory support or death occurred in 56 patients who received IVIG plus glucocorticoids (adjusted odds ratio for the comparison with IVIG alone, 0.77; 95% confidence interval [CI], 0.33 to 1.82) and in 17 patients who received glucocorticoids alone (adjusted odds ratio, 0.54; 95% CI, 0.22 to 1.33). The adjusted odds ratios for a reduction in disease severity were similar in the two groups, as compared with IVIG alone (0.90 for IVIG plus glucocorticoids and 0.93 for glucocorticoids alone). The time until a reduction in disease severity was similar in the three groups. CONCLUSIONS We found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue. Copyright © 2021 Massachusetts Medical Society.

Έτος δημοσίευσης:

2021

Συγγραφείς:

McArdle, A.J.
Vito, O.
Patel, H.
Seaby, E.G.
Shah, P.
Wilson, C.
Broderick, C.
Nijman, R.
Tremoulet, A.H.
Munblit, D.
Ulloa-Gutierrez, R.
Carter, M.J.
De, T.
Hoggart, C.
Whittaker, E.
Herberg, J.A.
Kaforou, M.
Cunnington, A.J.
Levin, M.
Vazquez, J.A.
Carmona, R.
Perez, L.
Rubinos, M.
Veliz, N.
Yori, S.
Haerynck, F.
Hoste, L.
Leal, I.A.
Da Silva, A.R.A.
Silva, A.E.A.
Barchik, A.
Barreiro, S.T.A.
Cochrane, N.
Teixeira, C.H.
Arauj, J.M.
Ossa, R.A.P.-D.L.
Vieira, C.S.
Dimitrova, A.
Ganeva, M.
Stefanov, S.
Telcharova-Mihaylovska, A.
Biggs, C.M.
Scuccimarri, R.
Withington, D.
Raul, B.B.
Ampuero, C.
Aravena, J.
Casanova, D.
Cruces, P.
Diaz, F.
Garcia-Salum, T.
Godoy, L.
Medina, R.A.
Galaz, G.V.
Avila-Aguero, M.L.
Brenes-Chacon, H.
Ivankovich-Escoto, G.
Yock-Corrales, A.
Badib, A.
Badreldin, K.
Elkhashab, Y.
Heshmat, H.
Heinonen, S.
Angoulvant, F.
Belot, A.
Ouldali, N.
Beske, F.
Heep, A.
Masjosthusmann, K.
Reiter, K.
Heuvel, I.V.D.
Both, U.V.
Agrafiotou, A.
Antachopoulos, C.
Eleftheriou, I.
Farmaki, E.
Fotis, L.
Kafetzis, D.
Lampidi, S.
Liakopoulou, T.
Maritsi, D.
Michailidou, E.
Milioudi, M.
Mparmpounaki, I.
Papadimitriou, E.
Papaevangelou, V.
Roilides, E.
Tsiatsiou, O.
Tsolas, G.
Tsolia, M.
Vantsi, P.
Pineda, L.Y.B.
Aguilar, K.L.B.
Quintero, E.M.C.
Ip, P.
Kwan, M.Y.W.
Kwok, J.
Lau, Y.L.
To, K.
Wong, J.S.C.
David, M.
Farkas, D.
Kalcakosz, S.
Szekeres, K.
Zsigmond, B.
Aslam, N.
Andreozzi, L.
Bianco, F.
Bucciarelli, V.
Buonsenso, D.
Cimaz, R.
D'Argenio, P.
Dellepiane, R.M.
Fabi, M.
Mastrolia, M.V.
Mauro, A.
Mazza, A.
Romani, L.
Simonini, G.
Tipo, V.
Valentini, P.
Verdoni, L.
Reel, B.
Pace, D.
Torpiano, P.
Flores, M.F.
Domínguez, M.G.
Vargas, A.L.G.
Hernandez, L.L.
Figueroa, R.P.M.
Gaxiola, G.P.
Valadez, J.
Klevberg, S.
Knudsen, P.K.
Maseide, P.H.
Carrera, J.M.
Castano, E.G.
Timana, C.A.D.
Leon, T.D.
Estripeaut, D.
Levy, J.
Norero, X.
Record, J.
Rojas-Bonilla, M.
Iramain, R.
Hernandez, R.
Huaman, G.
Munaico, M.
Peralta, C.
Seminario, D.
Yarleque, E.H.Z.
Gadzinska, J.
Mandziuk, J.
Okarska-Napierała, M.
Alacheva, Z.A.
Alexeeva, E.
Ananin, P.V.
Antsupova, M.
Bakradze, M.D.
Bobkova, P.
Borzakova, S.
Chashchina, I.L.
Fisenko, A.P.
Gautier, M.S.
Glazyrina, A.
Kondrikova, E.
Korobyants, E.
Korsunskiy, A.A.
Kovygina, K.
Krasnaya, E.
Kurbanova, S.
Kurdup, M.K.
Mamutova, A.V.
Mazankova, L.
Mitushin, I.L.
Nargizyan, A.
Orlova, Y.O.
Osmanov, I.M.
Polyakova, A.S.
Romanova, O.
Samitova, E.
Sologub, A.
Spiridonova, E.
Tepaev, R.F.
Tkacheva, A.A.
Yusupova, V.
Zholobova, E.
Grasa, C.D.
Segura, N.L.
Martinon-Torres, F.
Melendo, S.
Echevarria, A.M.
Guzman, J.M.M.
Argueta, J.R.P.
Rivero-Calle, I.
Riviere, J.
Rodriguez-Gonzalez, M.
Rojo, P.
Manubens, J.S.
Soler-Palacin, P.
Soriano-Arandes, A.
Tagarro, A.
Villaverde, S.
Altman, M.
Brodin, P.
Horne, A.
Palmblad, K.
Brotschi, B.
Sauteur, P.M.
Schmid, J.P.
Prader, S.
Relly, C.
Schlapbach, L.J.
Seiler, M.
Truck, J.
Wutz, D.
Ketharanathan, N.
Vermont, C.
Ozkan, E.A.
Erdeniz, E.H.
Borisova, G.
Boychenko, L.
Diudenko, N.
Kasiyan, O.
Katerynych, K.
Melnyk, K.
Miagka, N.
Teslenko, M.
Trykosh, M.
Volokha, A.
Akomolafe, T.
Al-Abadi, E.
Alders, N.
Avram, P.
Bamford, A.
Bank, M.
Roy, R.B.
Beattie, T.
Boleti, O.
Broad, J.
Carrol, E.D.
Chandran, A.
Cooper, H.
Davies, P.
Emonts, M.
Evans, C.
Fidler, K.
Foster, C.
Gong, C.
Gongrun, B.
Gonzalez, C.
Grandjean, L.
Grant, K.
Hacohen, Y.
Hall, J.
Hassell, J.
Hesketh, C.
Hewlett, J.
Hnieno, A.
Holt-Davis, H.
Hossain, A.
Hudson, L.D.
Johnson, M.
Johnson, S.
Jyothish, D.
Kampmann, B.
Kavirayani, A.
Kelly, D.
Kucera, F.
Langer, D.
Lillie, J.
Longbottom, K.
Lyall, H.
MacKdermott, N.
Maltby, S.
McLelland, T.
McMahon, A.-M.
Miller, D.
Morrison, Z.
Mosha, K.
Muller, J.
Myttaraki, E.
Nadel, S.
Osaghae, D.
Osman, F.
Ostrzewska, A.
Panthula, M.
Papachatzi, E.
Papadopoulou, C.
Penner, J.
Polandi, S.
Prendergast, A.J.
Ramnarayan, P.
Rhys-Evans, S.
Riordan, A.
Rodrigues, C.M.C.
Romaine, S.
Seddon, J.
Shingadia, D.
Srivastava, A.
Struik, S.
Taylor, A.
Taylor, A.
Taylor, A.
Tran, S.
Tudor-Williams, G.
Van Der Velden, F.
Ventilacion, L.
Wellman, P.A.
Yanney, M.P.
Yeung, S.
Badheka, A.
Badran, S.
Bailey, D.M.
Burch, A.K.
Burns, J.C.
Cichon, C.
Cirks, B.
Dallman, M.D.
Delany, D.R.
Fairchok, M.
Friedman, S.
Geracht, J.
Langs-Barlow, A.
Mann, K.
Padhye, A.
Quade, A.
Ramirez, K.A.
Rockett, J.
Sayed, I.A.
Shahin, A.A.
Umaru, S.
Widener, R.
Angela, M.H.
Kandawasvika, G.
BATS Consortium

Περιοδικό:

The New England journal of medicine

Εκδότης:

Massachussetts Medical Society

Τόμος:

385

Αριθμός / τεύχος:

Σελίδες:

11-22

Λέξεις-κλειδιά:

albumin; biological marker; blood marker; C reactive protein; ferritin; glucocorticoid; immunoglobulin; troponin; unclassified drug; glucocorticoid; immunoglobulin; virus antibody, Article; artificial ventilation; child; clinical feature; cohort analysis; coronary artery aneurysm; coughing; diarrhea; disease severity; echocardiography; female; fever; headache; heart left ventricle failure; hospitalization; human; hyperglycemia; hypertension; immunotherapy; inflammation; irritability; laboratory test; lethargy; lymphocyte; major clinical study; male; mucocutaneous lymph node syndrome; multiple organ failure; observational study; outcome assessment; pediatric multisystem inflammatory syndrome; preschool child; primary outcome; respiratory distress; school child; secondary outcome; sore throat; vomiting; adolescent; clinical trial; combination drug therapy; comparative study; confidence interval; immunology; immunomodulation; mortality; multicenter study; propensity score; regression analysis; systemic inflammatory response syndrome; treatment outcome, Adolescent; Antibodies, Viral; Child; Child, Preschool; Cohort Studies; Confidence Intervals; COVID-19; Drug Therapy, Combination; Female; Glucocorticoids; Hospitalization; Humans; Immunoglobulins, Intravenous; Immunomodulation; Male; Propensity Score; Regression Analysis; Respiration, Artificial; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Treatment Outcome

Επίσημο URL (Εκδότης):

https://doi.org/10.1056/NEJMoa2102968

DOI:

10.1056/NEJMoa2102968

Μόνιμη διεύθυνση:

https://pergamos.lib.uoa.gr/uoa/dl/object/3102187

Treatment of Multisystem Inflammatory Syndrome in Children

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