Τίτλος:
Potential Utility of Cardiorenal Biomarkers for Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Multiple different pathophysiologic processes can contribute to worsening renal function (WRF) in acute heart failure. Methods and Results: We retrospectively analyzed 787 patients with acute heart failure for the relationship between changes in serum creatinine and biomarkers including brain natriuretic peptide, high sensitivity cardiac troponin I, galectin 3, serum neutrophil gelatinase-associated lipocalin, and urine neutrophil gelatinase-associated lipocalin. WRF was defined as an increase of greater than or equal to 0.3 mg/dL or 50% in creatinine within first 5 days of hospitalization. WRF was observed in 25% of patients. Changes in biomarkers and creatinine were poorly correlated (r ≤ 0.21) and no biomarker predicted WRF better than creatinine. In the multivariable Cox analysis, brain natriuretic peptide and high sensitivity cardiac troponin I, but not WRF, were significantly associated with the 1-year composite of death or heart failure hospitalization. WRF with an increasing urine neutrophil gelatinase-associated lipocalin predicted an increased risk of heart failure hospitalization. Conclusions: Biomarkers were not able to predict WRF better than creatinine. The 1-year outcomes were associated with biomarkers of cardiac stress and injury but not with WRF, whereas a kidney injury biomarker may prognosticate WRF for heart failure hospitalization. © 2020 The Author(s)
Συγγραφείς:
HORIUCHI, Y.U.
WETTERSTEN, N.
VELDHUISEN, D.J.V.
MUELLER, C.
FILIPPATOS, G.
NOWAK, R.
HOGAN, C.
KONTOS, M.C.
CANNON, C.M.
MÜELLER, G.A.
BIRKHAHN, R.
TAUB, P.A.M.
VILKE, G.M.
BARNETT, O.L.G.A.
McDONALD, K.
MAHON, N.
NUÑEZ, J.
BRIGUORI, C.
PASSINO, C.
MAISEL, A.L.A.N.
MURRAY, P.T.
Περιοδικό:
Journal of Cardiac Failure
Λέξεις-κλειδιά:
angiotensin receptor antagonist; beta adrenergic receptor blocking agent; brain natriuretic peptide; creatinine; dipeptidyl carboxypeptidase inhibitor; diuretic agent; galectin 3; hemoglobin; neutrophil gelatinase associated lipocalin; sodium; troponin I; biological marker; creatinine; neutrophil gelatinase associated lipocalin, acute heart failure; aged; Article; chronic kidney failure; clinical assessment; controlled study; creatinine blood level; disease course; female; heart death; hospitalization; human; kidney dysfunction; kidney function; major clinical study; male; outcome assessment; prediction; priority journal; prognosis; retrospective study; risk assessment; risk factor; sensitivity analysis; urinalysis; heart failure; kidney; physiology; prognosis, Biomarkers; Creatinine; Heart Failure; Humans; Kidney; Lipocalin-2; Prognosis; Retrospective Studies
DOI:
10.1016/j.cardfail.2020.11.025
