Τίτλος:
Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood-brain barrier be a disease “sanctuary” during venetoclax treatment?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood-brain barrier and at what extend, especially in reduced doses given for drug-drug interactions. © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
Συγγραφείς:
Dimou, M.
Bitsani, A.
Roumelioti, M.
Dimitrakopoulou, A.
Iliakis, T.
Pardalis, V.
Grafakos, I.
Kalyva, S.
Markopoulos, A.
Kyrtsonis, M.-C.
Panayiotidis, P.
Περιοδικό:
Clinical Case Reports
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
azathioprine; CD20 antigen; CD23 antigen; CD5 antigen; CD79b antigen; chlorambucil; corticosteroid; cyclophosphamide; cyclosporine; cytochrome P450 3A; dexamethasone; fludarabine; ibrutinib; idelalisib; lactate dehydrogenase; methotrexate; petrafocon A HEM larafilcon A; rituximab; venetoclax, adult; Article; blood brain barrier; bone marrow biopsy; carcinomatous meningitis; case report; cell infiltration; cerebrospinal fluid analysis; chromosomal instability; chromosome aberration; chronic lymphatic leukemia; clinical article; cytogenetics; female; gene mutation; human; immunophenotyping; middle aged; nuclear magnetic resonance imaging; Sanger sequencing; splenomegaly
