Τίτλος:
Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Healthcare workers (HCWs) represent a high-risk population for infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Aim: To determine the seroprevalence of SARS-CoV-2 antibodies among HCWs, and identify the factors associated with this seroprevalence. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were applied for this systematic review and meta-analysis. Databases including PubMed/MEDLINE and preprint services (medRχiv and bioRχiv) were searched from inception to 24th August 2020. Findings: Forty-nine studies including 127,480 HCWs met the inclusion criteria. The estimated overall seroprevalence of SARS-CoV-2 antibodies among HCWs was 8.7% (95% confidence interval 6.7–10.9%). Seroprevalence was higher in studies conducted in North America (12.7%) compared with those conducted in Europe (8.5%), Africa (8.2) and Asia (4%). Meta-regression showed that increased sensitivity of antibody tests was associated with increased seroprevalence. The following factors were associated with seropositivity: male gender; Black, Asian and Hispanic HCWs; work in a coronavirus disease 2019 (COVID-19) unit; patient-related work; front-line HCWs; healthcare assistants; shortage of personal protective equipment; self-reported belief of previous SARS-CoV-2 infection; previous positive polymerase chain reaction test; and household contact with suspected or confirmed cases of COVID-19. Conclusion: The seroprevalence of SARS-CoV-2 antibodies among HCWs is high. Excellent adherence to infection prevention and control measures; sufficient and adequate personal protective equipment; and early recognition, identification and isolation of HCWs infected with SARS-CoV-2 are imperative to decrease the risk of SARS-CoV-2 infection. © 2020 The Healthcare Infection Society
Συγγραφείς:
Galanis, P.
Vraka, I.
Fragkou, D.
Bilali, A.
Kaitelidou, D.
Περιοδικό:
JOURNAL OF HOSPITAL INFECTION
Εκδότης:
W.B. Saunders Ltd
Λέξεις-κλειδιά:
SARS-CoV-2 antibody; virus antibody, antibody detection; Asian; Black person; comorbidity; convenience sample; health care facility; health care personnel; Hispanic; home quarantine; human; infection prevention; infection risk; meta analysis; nonhuman; occupational exposure; Review; risk assessment; seroprevalence; Severe acute respiratory syndrome coronavirus 2; sex difference; systematic review; adult; Africa; Asia; blood; diagnosis; disease transmission; epidemiology; Europe; female; genetics; health care personnel; immunology; male; middle aged; North America; prevention and control; procedures; protective equipment; protocol compliance; risk factor; self report; sensitivity and specificity; seroepidemiology; virology, Adult; Africa; Antibodies, Viral; Asia; COVID-19; COVID-19 Serological Testing; Europe; Female; Guideline Adherence; Health Personnel; Humans; Infectious Disease Transmission, Patient-to-Professional; Male; Middle Aged; North America; Personal Protective Equipment; Risk Factors; SARS-CoV-2; Self Report; Sensitivity and Specificity; Seroepidemiologic Studies
DOI:
10.1016/j.jhin.2020.11.008
