Τίτλος:
Increased Red Cell Distribution Width Is Associated With Disease Severity in Hospitalized Adults With SARS-CoV-2 Infection: An Observational Multicentric Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: There is an amenable need for clinically applicable biomarkers in patients with SARS-CoV-2 infection. Red Cell Distribution Width (RDW) has been recently suggested as a prognostic biomarker for COVID-19. Methods: This was an observational study enrolling patients between February 26 and May 15 2020. We aimed to validate the association of the previously published RDW threshold of 14.5% with markers of disease progression and mortality. Results: A total number of 193 hospitalized patients with COVID-19 were enrolled and analyzed. Median age was 61 years (95% CI: 58–64). Patients with baseline RDW ≥14.5% (n = 41, 19.2%) presented with more progressive disease compared to patients with baseline RDW <14.5% (n = 156, 80.8%) as indicated by significant differences in maximum FiO2% during hospitalization (median: 100, 95% CI: 45.2–100, vs. 35, 95% CI: 31–40, p = 0.0001, respectively). Values of RDW ≥14.5% were also strongly associated with increased risk of mortality (HR: 4.1, 95% CI: 0.88–19.23), (p = 0.02). Conclusion: Our study provides evidence to support reproducibility and validity of a specified cut-off threshold of RDW as biomarker of disease severity and mortality in patients with COVID-19. © Copyright © 2020 Karampitsakos, Akinosoglou, Papaioannou, Panou, Koromilias, Bakakos, Loukides, Bouros, Gogos and Tzouvelekis.
Συγγραφείς:
Karampitsakos, T.
Akinosoglou, K.
Papaioannou, O.
Panou, V.
Koromilias, A.
Bakakos, P.
Loukides, S.
Bouros, D.
Gogos, C.
Tzouvelekis, A.
Περιοδικό:
Frontiers in Cardiovascular Medicine
Εκδότης:
Frontiers Media S.A
Λέξεις-κλειδιά:
anakinra; antibiotic agent; azithromycin; biological marker; colchicine; hydroxychloroquine; lopinavir plus ritonavir; low molecular weight heparin; remdesivir; tocilizumab, adult; Article; controlled study; coronavirus disease 2019; disease course; disease severity; female; Greece; hospital patient; hospitalization; human; human cell; major clinical study; male; mortality; mortality risk; multicenter study; observational study; red blood cell distribution width; reproducibility; Severe acute respiratory syndrome coronavirus 2; validity
DOI:
10.3389/fmed.2020.616292
