Τίτλος:
Mitophagy Balance in Various Cell Subsets in Patients with ANCA-Associated Vasculitis and Correlation with the Presence of Anti-Neutrophil Cytoplasmic Antibodies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
ANCA-associated vasculitides (AAVs) are characterised by heterogeneous molecular and patho-physiological traits, causing ambiguous differential diagnosis and taxonomy. Response to therapyhas pro ven far from successful, contributing to high mortality. Transcriptome analysis of differentvasculitis subtypes adds new leads in elucidating mechanisms of disease and the role of specific cellsubsets to them. Recent findings have shown that mitophagy is a procedure whose imbalance couldlead to immune dysregulation with certain involvement to autoimmunity. Inflammatory response related mitophagy is yet to be described in AAVs. We here describe a research protocol to investigate mitophagy in monocytes, neutrophils, and T cells in AAV patients, and the relationship of disturbed mitophagy with ANCA seropositivity. ©Aggelos Banos
Συγγραφείς:
Banos, A.
Garantziotis, P.
Malissovas, N.
Filia, A.
Boumpas, D.T.
Thomas, K.
Moustafa, S.
Panagiotopoulos, A.
Vassilopoulos, D.
Garantziotis, P.
Pieta, A.
Nikolopoulos, D.
Boumpas, D.T.
Περιοδικό:
Mediterranean Journal of Rheumatology
Εκδότης:
Greek Rheumatology Society and Professional Association of Rheumatologists
Λέξεις-κλειδιά:
neutrophil cytoplasmic antibody, ANCA associated vasculitis; antibody detection; Article; autoimmunity; cell subpopulation; clinical article; clinical protocol; cohort analysis; comparative study; controlled study; correlational study; disease activity; disease association; human; human cell; mitophagy; monocyte; neutrophil; phenotype; regulatory mechanism; T lymphocyte; transcriptomics; validation study
DOI:
10.31138/mjr.31.3.366
