Τίτλος:
Stem cells in ductal breast cancer: Immunohistochemical expression of CD44, CD24, CD133, and ALDH-1 markers in 104 cases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The aim of this study was to evaluate the immunohistochemical expression of stem cell markers CD44, CD24, CD133, and ALDH-1 in breast carcinomas and investigate any correlation with stage, degree of tumor differentiation, cell proliferation index, and hormone receptors status. Materials and Methods: One hundred and four cases of invasive ductal breast carcinomas were studied and classified according to grade and stage, hormonal status, and C-erbB2 expression. A semi-automatic Ventana method was used to examine by semi-quantitative method the immunohistochemical expression of anti-CD133, CD24, CD44, and ALDH1 antibodies. Results: CD44, CD24, and ALDH1 markers demonstrated a statistically significant correlation with higher disease stage and triple negative cancers (94%-55.5%). CD133 correlated with triple negative cancers (55.5%). No correlation with other clinical data or tumor differentiation was observed. Conclusion: Triple negative breast cancers express specific stem cell markers responsible for cell/stroma interaction and this is a useful tool in predicting tumor progression and developing specific targeted therapies. © 2020 S.O.G. CANADA Inc.. All rights reserved.
Συγγραφείς:
Korfias, D.
Contis, J.
Frangou-Plemenou, M.
Gennatas, K.
Kondis, A.
Vlachodimitropoulos, D.
Περιοδικό:
European Journal of Gynaecological Oncology
Εκδότης:
IMR Press Limited
Λέξεις-κλειδιά:
aldehyde dehydrogenase isoenzyme 1; CD133 antigen; CD24 antigen; epidermal growth factor receptor 2; Hermes antigen, adult; aged; Article; breast carcinoma; cancer size; cancer stem cell; cell membrane; cell proliferation; human; human cell; immunohistochemistry; major clinical study; triple negative breast cancer; tumor differentiation
DOI:
10.31083/j.ejgo.2020.01.4810
