Τίτλος:
CGRP and migraine from a cardiovascular point of view: What do we expect from blocking CGRP?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors are distributed not only in the central and peripheral nervous system but also in the cardiovascular system, both in blood vessels and in the heart. We reviewed the current evidence on the role of CGRP in the cardiovascular system in order to understand the possible short- and long-term effect of CGRP blockade with monoclonal antibodies in migraineurs. In physiological conditions, CGRP has important vasodilating effects and is thought to protect organs from ischemia. Despite the aforementioned cardiovascular implication, preventive treatment with CGRP antibodies has shown no relevant cardiovascular side effects. Results from long-term trials and from real life are now needed. © 2019 The Author(s).
Συγγραφείς:
Favoni, V.
Giani, L.
Al-Hassany, L.
Asioli, G.M.
Butera, C.
De Boer, I.
Guglielmetti, M.
Koniari, C.
Mavridis, T.
Vaikjärv, M.
Verhagen, I.
Verzina, A.
Zick, B.
Martelletti, P.
Sacco, S.
Περιοδικό:
The Journal of Headache and Pain
Εκδότης:
BioMed Central Ltd.
Λέξεις-κλειδιά:
calcitonin gene related peptide; calcitonin gene related peptide receptor antagonist; cyclic AMP; calcitonin gene related peptide; calcitonin gene related peptide receptor; monoclonal antibody, cardiovascular system; endothelial dysfunction; hemodynamic parameters; long term survival; migraine; neuropathology; nonhuman; pathophysiology; priority journal; Review; sex difference; short term survival; antagonists and inhibitors; cardiovascular system; human; migraine; physiology; sex factor; vasodilatation, Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cardiovascular System; Humans; Migraine Disorders; Receptors, Calcitonin Gene-Related Peptide; Sex Factors; Vasodilation
DOI:
10.1186/s10194-019-0979-y
