Τίτλος:
Prevalence of underweight, overweight, and obesity in children and adolescents with type 1 diabetes: Data from the international SWEET registry
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To assess the prevalence of underweight (UW), overweight (OW), and obesity in children and adolescents with type 1 diabetes (T1D). Methods: An international cross-sectional study including 23 026 T1D children (2-18 years, duration of diabetes ≥1 year) participating in the SWEET prospective, multicenter diabetes registry. Body mass index SD score (BMI-SDS) was calculated using the World Health Organization BMI charts. Children were categorized as UW (BMI-SDS < −2SD), OW (+1SD < BMI-SDS ≤ +2SD), and obese (OB) (BMI-SDS > +2SD). Hierarchic regression models were applied with adjustment for sex, age, and duration of diabetes. Results: The prevalence of UW, OW, and obesity was: 1.4%, 22.3%, and 7.3% in males and 0.6%, 27.2%, and 6.8% in females. Adjusted BMI-SDS was significantly higher in females than in males (mean ± SEM: 0.54 ± 0.05 vs 0.40 ± 0.05, P < 0.0001). In males, BMI-SDS significantly decreased by age (P < 0.0001) in the first three age categories 0.61 ± 0.06 (2 to <10 years), 0.47 ± 0.06 (10 to <13 years), 0.34 ± 0.05 (13 to <16 years). In females, BMI-SDS showed a U-shaped distribution by age (P < 0.0001): 0.54 ± 0.04 (2 to <10 years), 0.39 ± 0.04 (10 to <13 years), 0.55 ± 0.04 (13 to <16 years). BMI-SDS increased by diabetes duration (<2 years: 0.38 ± 0.05, 2 to <5 years: 0.44 ± 0.05, and ≥5 years: 0.50 ± 0.05, P < 0.0001). Treatment modality did not affect BMI-SDS. Adjusted HbA1c was significantly higher in females than in males (8.20% ± 0.10% vs 8.06% ± 0.10%, P < 0.0001). In both genders, the association between HbA1c and BMI-SDS was U-shaped with the highest HbA1c in the UW and obesity groups. Conclusions: The high rate of OW and obesity (31.8%) emphasize the need for developing further strategies to prevent and treat excess fat accumulation in T1D. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Συγγραφείς:
Maffeis, C.
Birkebaek, N.H.
Konstantinova, M.
Schwandt, A.
Vazeou, A.
Casteels, K.
Jali, S.
Limbert, C.
Pundziute-Lycka, A.
Toth-Heyn, P.
de Beaufort, C.
Sumnik, Z.
Cherubini, V.
Svensson, J.
Pacaud, D.
Kanaka-Gantenbein, C.
Shalitin, S.
Bratina, N.
Hanas, R.
Alonso, G.T.
Poran, L.
Pereira, A.L.
Marigliano, M.
The SWEET Study Group
Περιοδικό:
Pediatric Diabetes
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
hemoglobin A1c; insulin, adolescent; adult; age; age distribution; Article; body mass; child; clinical assessment; clinical feature; cross-sectional study; disease association; disease course; disease duration; disease registry; female; human; insulin dependent diabetes mellitus; insulin treatment; lipid storage; major clinical study; male; obesity; pediatrics; prevalence; priority journal; prophylaxis; sex difference; therapy effect; treatment outcome; underweight; clinical trial; complication; insulin dependent diabetes mellitus; multicenter study; obesity; preschool child; prevalence; register; underweight, Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Female; Humans; Male; Obesity; Prevalence; Registries; Thinness
