Ερευνητικό υλικό ΕΚΠΑ

Identifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations

Αγγλικά

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © 2014 The Author.

2014

Van Os, J.
Rutten, B.P.
Myin-Germeys, I.
Delespaul, P.
Viechtbauer, W.
Van Zelst, C.
Bruggeman, R.
Reininghaus, U.
Morgan, C.
Murray, R.M.
Di Forti, M.
McGuire, P.
Valmaggia, L.R.
Kempton, M.J.
Gayer-Anderson, C.
Hubbard, K.
Beards, S.
Stilo, S.A.
Onyejiaka, A.
Bourque, F.
Modinos, G.
Tognin, S.
Calem, M.
O'Donovan, M.C.
Owen, M.J.
Holmans, P.
Williams, N.
Craddock, N.
Richards, A.
Humphreys, I.
Meyer-Lindenberg, A.
Leweke, F.M.
Tost, H.
Akdeniz, C.
Rohleder, C.
Bumb, J.M.
Schwarz, E.
Alptekin, K.
Üçok, A.
Saka, M.C.
Atbagoǧlu, E.C.
Gülöksüz, S.
Gumus-Akay, G.
Cihan, B.
Karadaǧ, H.
Soygür, H.
Cankurtaran, E.S.
Ulusoy, S.
Akdede, B.
Binbay, T.
Ayer, A.
Noyan, H.
Karadayi, G.
Akturan, E.
Ulaş, H.
Arango, C.
Parellada, M.
Bernardo, M.
Sanjuán, J.
Bobes, J.
Arrojo, M.
Santos, J.L.
Cuadrado, P.
Solano, J.J.R.
Carracedo, A.
Bernardo, E.G.
Roldán, L.
López, G.
Cabrera, B.
Cruz, S.
Mesa, E.M.D.
Pouso, M.
Jiménez, E.
Sánchez, T.
Rapado, M.
González, E.
Martínez, C.
Sánchez, E.
Olmeda, M.S.
De Haan, L.
Velthorst, E.
Van Der Gaag, M.
Selten, J.-P.
Van Dam, D.
Van Der Ven, E.
Van Der Meer, F.
Messchaert, E.
Kraan, T.
Burger, N.
Leboyer, M.
Szoke, A.
Schürhoff, F.
Llorca, P.-M.
Jamain, S.
Tortelli, A.
Frijda, F.
Vilain, J.
Galliot, A.-M.
Baudin, G.
Ferchiou, A.
Richard, J.-R.
Bulzacka, E.
Charpeaud, T.
Tronche, A.-M.
De Hert, M.
Van Winkel, R.
Decoster, J.
Derom, C.
Thiery, E.
Stefanis, N.C.
Sachs, G.
Aschauer, H.
Lasser, I.
Winklbaur, B.
Schlögelhofer, M.
Riecher-Rössler, A.
Borgwardt, S.
Walter, A.
Harrisberger, F.
Smieskova, R.
Rapp, C.
Ittig, S.
Soguel-Dit-Piquard, F.
Studerus, E.
Klosterkötter, J.
Ruhrmann, S.
Paruch, J.
Julkowski, D.
Hilboll, D.
Sham, P.C.
Cherny, S.S.
Chen, E.Y.H.
Campbell, D.D.
Li, M.
Romeo-Casabona, C.M.
Cirión, A.E.
Mora, A.U.
Jones, P.
Kirkbride, J.
Cannon, M.
Rujescu, D.
Tarricone, I.
Berardi, D.
Bonora, E.
Seri, M.
Marcacci, T.
Chiri, L.
Chierzi, F.
Storbini, V.
Braca, M.
Minenna, M.G.
Donegani, I.
Fioritti, A.
La Barbera, D.
La Cascia, C.E.
Mulè, A.
Sideli, L.
Sartorio, R.
Ferraro, L.
Tripoli, G.
Seminerio, F.
Marinaro, A.M.
McGorry, P.
Nelson, B.
Amminger, G.P.
Pantelis, C.
Menezes, P.R.
Del-Ben, C.M.
Tenan, S.H.G.
Shuhama, R.
Ruggeri, M.
Tosato, S.
Lasalvia, A.
Bonetto, C.
Ira, E.
Nordentoft, M.
Krebs, M.-O.
Barrantes-Vidal, N.
Cristóbal, P.
Kwapil, T.R.
Brietzke, E.
Bressan, R.A.
Gadelha, A.
Maric, N.P.
Andric, S.
Mihaljevic, M.
Mirjanic, T.

Schizophrenia Bulletin

Oxford University Press

40

4

729-736

allele; article; attributable risk; copy number variation; environmental exposure; environmental factor; genetic association; genetic risk; genetic variability; genetics; genotype; genotype environment interaction; heredity; human; priority journal; risk assessment; schizophrenia; single nucleotide polymorphism; genetic predisposition; genetics; psychology; schizophrenia; social environment, Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Schizophrenia; Schizophrenic Psychology; Social Environment

https://doi.org/10.1093/schbul/sbu069

10.1093/schbul/sbu069

https://pergamos.lib.uoa.gr/uoa/dl/object/3110778