Τίτλος:
Mortality from cancer and other causes in commercial airline crews: A joint analysis of cohorts from 10 countries
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Commercial airline crew is one of the occupational groups with the highest exposures to ionising radiation. Crew members are also exposed to other physical risk factors and subject to potential disruption of circadian rhythms. Methods: This study analyses mortality in a pooled cohort of 93 771 crew members from 10 countries. The cohort was followed for a mean of 21.7 years (2.0 million person-years), during which 5508 deaths occurred. Results: The overall mortality was strongly reduced in male cockpit (SMR 0.56) and female cabin crews (SMR 0.73). The mortality from radiation-related cancers was also reduced in male cockpit crew (SMR 0.73), but not in female or male cabin crews (SMR 1.01 and 1.00, respectively). The mortality from female breast cancer (SMR 1.06), leukaemia and brain cancer was similar to that of the general population. The mortality from malignant melanoma was elevated, and significantly so in male cockpit crew (SMR 1.57). The mortality from cardiovascular diseases was strongly reduced (SMR 0.46). On the other hand, the mortality from aircraft accidents was exceedingly high (SMR 33.9), as was that from AIDS in male cabin crew (SMR 14.0). Conclusions: This large study with highly complete follow-up shows a reduced overall mortality in male cockpit and female cabin crews, an increased mortality of aircraft accidents and an increased mortality in malignant skin melanoma in cockpit crew. Further analysis after longer follow-up is recommended.
Συγγραφείς:
Hammer, G.P.
Auvinen, A.
De Stavola, B.L.
Grajewski, B.
Gundestrup, M.
Haldorsen, T.
Hammar, N.
Lagorio, S.
Linnersjö, A.
Pinkerton, L.
Pukkala, E.
Rafnsson, V.
Dos-Santos-Silva, I.
Storm, H.H.
Strand, T.-E.
Tzonou, A.
Zeeb, H.
Blettner, M.
Περιοδικό:
Annals of Occupational and Environmental Medicine
Εκδότης:
BMJ Publishing Group
Λέξεις-κλειδιά:
aircraft accident; airplane crew; article; brain cancer; breast cancer; cancer mortality; cardiovascular disease; cohort analysis; crew member; female; follow up; human; leukemia; major clinical study; male; melanoma; occupational health; priority journal; sex difference, Accidents, Aviation; Acquired Immunodeficiency Syndrome; Aircraft; Brain Neoplasms; Breast Neoplasms; Cardiovascular Diseases; Cause of Death; Circadian Rhythm; Cohort Studies; Cosmic Radiation; Europe; Female; Humans; Leukemia; Male; Melanoma; Middle Aged; Neoplasms; Neoplasms, Radiation-Induced; Occupational Diseases; Occupational Exposure; Occupations; Risk Factors; Sex Factors; United States
DOI:
10.1136/oemed-2013-101395
