Τίτλος:
Association between low-grade systemic inflammation and type 2 diabetes mellitus among men and women from the ATTICA study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
AIM: The aim is to investigate the relationship between low-grade inflammation and several glycemic indices in a population-based sample of men and women. METHODS: The ATTICA study is a population-based cohort that randomly enrolled 1514 men and 1528 women (aged >18 years old), stratified by age and gender, from the Greater Athens area, during 2001-2002. Among several characteristics, inflammation markers (high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, homocysteine and amyloid A) and glycemic control indices (fasting blood glucose, insulin, HOMA) were measured in the participants. RESULTS: The prevalence of diabetes was 7.8% in men and 6.0% in women. The prevalence of impaired fasting glucose (IFG) was 21% in men and 12% in women. Diabetic subjects had 57% higher mean levels of C-reactive protein (p < 0.001), 22% higher mean levels of interleukin-6 (p < 0.001) and 60% higher levels of tumor necrosis factor-alpha (p < 0.001) compared to non-diabetic subjects. Homocysteine and serum amyloid A levels did not show significant differences among groups. CONCLUSION: Our study supports a positive association between low-grade inflammation and diabetes in a population-based sample of men and women without any evidence of cardiovascular disease, which is independent of demographic, clinical and lifestyle characteristics, including physical activity and dietary factors. Copyright © by the SBDR.
Συγγραφείς:
Pitsavos, C.
Tampourlou, M.
Panagiotakos, D.B.
Skoumas, Y.
Chrysohoou, C.
Nomikos, T.
Stefanadis, C.
Περιοδικό:
The Review of Diabetic Studies : RDS
Λέξεις-κλειδιά:
amyloid A protein; C reactive protein; glucose; homocysteine; interleukin 6; tumor necrosis factor alpha, adult; aged; article; diet; female; glucose blood level; human; hypercholesterolemia; hypertension; inflammation; major clinical study; male; non insulin dependent diabetes mellitus; obesity; physical activity; prevalence; smoking
DOI:
10.1900/RDS.2007.4.98
